N-maleinimidyl-3-(2-pyridyldithio)propionate | 604799-80-6

• 分子结构分类: 有机化合物
• 英文名称: N-maleinimidyl-3-(2-pyridyldithio)propionate
• 英文别名: (2,5-Dioxopyrrol-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
• CAS: 604799-80-6
• 化学式: C₁₂H₁₀N₂O₄S₂
• 分子量: 310.354
• InChiKey: BNLLFJFIIBMLII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Desmosine derivatives and reagent for preparing artificial antigens
  申请人：JAPAN TOBACCO INC.

  公开号：EP0196007A2

  公开（公告）日：1986-10-01

  A novel desmosine derivative, which is useful for preparing a desmosine artificial antigen, has an activated, disulfide bond on the side chain at 3 or 5 position of the pyridinium ring. The derivative can combine with a polymer having thiel groups by a disulfide bond to form the effective artificial antigen.

  一种新型去氨腺苷衍生物可用于制备去氨腺苷人工抗原，它在吡啶鎓环的 3 或 5 位侧链上有一个活化的二硫键。该衍生物可通过二硫键与具有巯基的聚合物结合，形成有效的人工抗原。
• Biological indicator
  申请人：Cregger Tricia A.

  公开号：US20080199903A1

  公开（公告）日：2008-08-21

  A biological indicator for monitoring the effectiveness of a sterilizing, disinfecting, etc., compound or condition is disclosed which comprises a substrate having a surface layer containing functional groups thereon desirably free of silicone linking groups. The functional groups are desirably in the form of a monolayer of a uniformed distribution and of a selected quantity. Various types of microorganisms such as spores and/or etiological agents are covalently bonded to the surface layer functional groups through a crosslinking reagent and thus form a uniform number and distribution of the microorganisms and/or etiological agents. After being subjected to sterilization or other similar treatment, etc., along with various articles such as instruments, the indicator can be cultivated to determine the effectiveness of the sterilization, disinfection, etc. process.
• ANTI-CCR7 ANTIBODY DRUG CONJUGATES
  申请人：NOVARTIS AG

  公开号：US20200216548A1

  公开（公告）日：2020-07-09

  This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
• US4723012A
  申请人：——

  公开号：US4723012A

  公开（公告）日：1988-02-02
• US4841055A
  申请人：——

  公开号：US4841055A

  公开（公告）日：1989-06-20