3-羟基-2-碘苯甲酸 | 75821-44-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-羟基-2-碘苯甲酸
• 英文名称: 3-hydroxy-2-iodobenzoic acid
• 英文别名: 3-Hydroxy-2-jod-benzoesaeure
• CAS: 75821-44-2
• 化学式: C₇H₅IO₃
• 分子量: 264.019
• InChiKey: YCPLPINFTMFQTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-羟基-2-碘苯甲酸 在 copper bronze 、 硫酸 、 potassium carbonate 作用下， 以 异戊醇 为溶剂， 反应 10.0h， 生成 1,5-dihydroxy-2,3-dimethoxy-9-acridone
  参考文献：
  名称：

  Alkaloids from the stem of Glycosmis bilocularis (Rutaceae)

  摘要：

  DOI：

  10.1016/0031-9422(80)80229-9
• 作为产物：
  描述：

  3-acetoxy-2-iodo-benzoic acid 在 氢氧化钾 作用下， 生成 3-羟基-2-碘苯甲酸
  参考文献：
  名称：

  Henry; Sharp, Journal of the Chemical Society, 1935, p. 857

  摘要：

  DOI：

文献信息

• Method of treating cancer
  申请人：——

  公开号：US20030220241A1

  公开（公告）日：2003-11-27

  The present invention relates to methods of treating cancer using a combination of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种PSA共轭物和一种前脂蛋白转移酶抑制剂的组合治疗癌症的方法，该方法包括向所述哺乳动物施用来自以下组中选择的至少两种治疗剂的量，所述组包括一种PSA共轭物和一种前脂蛋白转移酶抑制剂，所述治疗剂可以顺序给药或同时给药。该发明还涉及制备这种组合物的方法。
• [EN] A METHOD OF TREATING CANCER<br/>[FR] UNE METHODE POUR LE TRAITEMENT DU CANCER
  申请人：MERCK & CO INC

  公开号：WO2000059930A1

  公开（公告）日：2000-10-12

  The present invention relates to methods of treating cancer using a combination of a compound which is a PSA conjugate and a compound which is an inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is a PSA conjugate and a compound which is an inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种PSA共轭物和一种前尼基蛋白转移酶抑制剂的组合治疗癌症的方法，该方法包括向哺乳动物施用至少两种治疗剂量，所述治疗剂量从以下组合中选择：一种是PSA共轭物，一种是前尼基蛋白转移酶抑制剂，无论是按顺序或同时施用。本发明还涉及制备这种组合物的方法。
• Inhibitors of prenyl-protein transferase
  申请人：Merck & Co., Inc.

  公开号：US20020037888A1

  公开（公告）日：2002-03-28

  The present invention is directed to compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

  本发明涉及抑制前醇基-蛋白质转移酶（FTase）和致癌基因蛋白Ras的前醇化的化合物。该发明进一步涉及含有本发明化合物的化疗组合物以及抑制前醇基-蛋白质转移酶和致癌基因蛋白Ras的方法。
• Compositions for Chemical and Biological Defense
  申请人：Hatton Trevor Alan

  公开号：US20110027869A1

  公开（公告）日：2011-02-03

  One aspect of the present invention relates to reactive compositions and methods of use thereof, wherein a metal oxide cluster is used to connect a reactive group (or groups) to the surface of a substrate. In certain embodiments, the reactive group in the compositions decomposes organophosphate agents through nucleophilic hydrolysis. In certain embodiments, the reactive group in the compositions is bactericidal. Remarkably, the use of metal oxide clusters in the disclosed compositions and methods permits incorporation of higher quantities of nucleophilic and bactericidal groups without the difficulties associated with having to pretreat the substrate prior to its association with the reactive groups.

  本发明的一个方面涉及反应性组合物及其使用方法，其中金属氧化物簇用于将反应性基团（或基团）连接到基底表面上。在某些实施例中，组合物中的反应性基团通过亲核水解分解有机磷酸酯剂。在某些实施例中，组合物中的反应性基团具有杀菌作用。值得注意的是，所述组合物和方法中使用金属氧化物簇允许将更多的亲核和杀菌基团纳入其中，而无需在与反应性基团结合之前对基底进行预处理。
• PROCESS FOR PRODUCTION OF PHENOL DERIVATIVES SUBSTITUTED WITH IODINE AT ORTHO POSITION
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2199271A1

  公开（公告）日：2010-06-23

  A process in which a phenol derivative is iodinated to produce a 2-iodophenol or 2,6-diiodophenol derivative substituted with iodine at an ortho position thereof is provided, which does not require any step of recovery of iodine but can produce it at low cost, in high yield and with high quality. A phenol derivative is mixed with a pyridine and hydrogen peroxide or iodic acid as an oxidizing agent, and reacted with molecular iodine. As a result, iodination can be performed very efficiently with iodine in an amount close to the theoretical amount relative to the phenol derivative, and the 2-iodophenol or 2,6-diiodophenol derivative can be obtained in high yield and with high quality.

  本发明提供了一种将苯酚衍生物碘化以生产在其正位被碘取代的 2-碘苯酚或 2,6- 二碘苯酚衍生物的工艺，该工艺不需要任何碘回收步骤，但能以低成本、高产率和高质量生产苯酚衍生物。将苯酚衍生物与吡啶和作为氧化剂的过氧化氢或碘酸混合，然后与分子碘反应。因此，碘的用量与苯酚衍生物的理论用量相近，可以非常有效地进行碘化反应，从而可以高产率、高质量地获得 2-碘苯酚或 2,6-二碘苯酚衍生物。