3-羟基-2-苯氧基-丙酸 | 408338-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-羟基-2-苯氧基-丙酸
• 英文名称: 3-hydroxy-2-phenoxy-propionic acid
• 英文别名: 3-Hydroxy-2-phenoxy-propionsaeure；Hydroxymethylphenoxyacetic acid；3-hydroxy-2-phenoxypropanoic acid
• CAS: 408338-64-7
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: HWJNMTWBPYQWKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-羟基-2-苯氧基-丙酸 、 苯胺 生成 3-hydroxy-2-phenoxy-propionic acid anilide
  参考文献：
  名称：

  THE MONOPHENYL ETHERS OF GLYCERIC ACID

  摘要：

  DOI：

  10.1021/ja01369a038
• 作为产物：
  描述：

  苯酚 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 、 水 作用下， 生成 3-羟基-2-苯氧基-丙酸 、 rac-2-羟基-3-苯氧基丙酸
  参考文献：
  名称：

  THE MONOPHENYL ETHERS OF GLYCERIC ACID

  摘要：

  DOI：

  10.1021/ja01369a038

文献信息

• [EN] TUMOUR-TARGETING PEPTIDE VARIANTS<br/>[FR] VARIANTS PEPTIDIQUES CIBLANT DES TUMEURS
  申请人：CANCER RESEARCH TECH LTD

  公开号：WO2018197490A1

  公开（公告）日：2018-11-01

  The present invention provides a peptide that selectively binds ανβ6 integrin, the peptide having an amino acid sequence comprising the motif X1BnRGDLX2X3X4 ZmX5, wherein X1 is any D-amino acid, Bn is a sequence of any n amino acids, which may be natural or unnatural, D- or L-, and may be the same or different, wherein n is a number between 1 and 10, X2 and X3 are independently selected from any amino acid, X4 is Leu or Ile, Zm is a sequence of any m amino acids, which may be natural or unnatural, D- or L-, and may be the same or different, wherein m is a number between 1 and 10, X5 is any L- or D-amino acid. Also provided are conjugates comprising said peptide, pharmaceutical compositions comprising said peptide or said conjugates, and uses of said peptide, conjugate or composition, for example, in the treatment, imaging and/or diagnosis of an ανβ6- expressing tumour in a mammalian subject.

  本发明提供了一种选择性结合ανβ6整合素的肽，该肽具有氨基酸序列，包括基序X1BnRGDLX2X3X4 ZmX5，其中X1是任何D-氨基酸，Bn是任何n个氨基酸的序列，可以是天然的或非天然的，D-或L-，可以相同也可以不同，其中n是1到10之间的数字，X2和X3分别选自任何氨基酸，X4是Leu或Ile，Zm是任何m个氨基酸的序列，可以是天然的或非天然的，D-或L-，可以相同也可以不同，其中m是1到10之间的数字，X5是任何L-或D-氨基酸。还提供了包括所述肽的结合物，包括所述肽或所述结合物的药物组合物，以及所述肽，结合物或组合物的用途，例如，在治疗、成像和/或诊断哺乳动物主体中表达ανβ6的肿瘤。
• Polyhydroxy phenols and their use in binding p-selectin
  申请人：Biessen Leonardus Erik Anna

  公开号：US20060276545A1

  公开（公告）日：2006-12-07

  Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.

  本发明提供了多羟基酚，其是没肽基的没食子酸肽类似物，并提供了使用提供没食子酸基团的方法制备没食子酸衍生物，以及含有多羟基酚的药用和营养成分组合物。本发明还提供了将多羟基酚用作药物，特别是用于制造用于预防、治疗或诊断涉及P选择素的疾病或病症的药物。同样的化合物也可用作定向工具，用于在组合物中靶向表达P选择素的细胞或组织，进一步包括载体中的活性化合物。
• Novel peptides
  申请人：KAO CORPORATION

  公开号：EP0352560A1

  公开（公告）日：1990-01-31

  The present invention relates to physiologically active peptides and more particularly, to novel peptides having a specific amino acid sequence which possess a macrophage chemotactic activity; and represented by formula: m-A-B-C-D-E-F-G-H-I-n corresponding, also to the following exemples H-Trp-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH or H-Arg-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH wherein X represents Glu or Gln, and a salt thereof.

  本发明涉及生理活性肽，更具体地说，涉及具有特定氨基酸序列的新型肽，这些肽具有巨噬细胞趋化活性；并由式表示： m-A-B-C-D-E-F-G-H-I-n 相应的还有以下示例 H-Trp-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH 或 H-Arg-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH 其中 X 代表 Glu 或 Gln 及其盐。
• Solid phase multiple peptide synthesis
  申请人：RHONE-POULENC RORER PHARMACEUTICALS INC.

  公开号：EP0400920A1

  公开（公告）日：1990-12-05

  Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.

  本发明提供了在透明表面上生产寡肽的方法和组合物，同时通过循环添加受保护的单体来保持透明度。试剂经过特别挑选，可以有效地重复添加，同时保持支撑物的透明度。所提供的连接剂可使寡肽保留在表面上，或在完成寡肽制备时释放出来。与载体结合的寡肽可用于诊断检测和其他应用，而游离的寡肽则可用于多种用途。
• Anti-microbial compositions
  申请人：UNILEVER N.V.

  公开号：EP0721774A2

  公开（公告）日：1996-07-17

  The present invention relates to anti-microbial cosmetic compositions for the care of the human body or parts thereof, comprising derivatives of histatins or fragments thereof. It has been found that the anti-microbial activity of histatins or their fragments can be significantly enhanced by capping them at the C-terminus or at the C- and N-terminus and/or complexing them with anti-microbially-active metal ions. The thus modified histatins and histatin fragments were found to have a significantly increased activity against a range of microbial strains, and were found to be useful as controlled delivery agents for the metal ions. They are suitable for a whole range of anti-microbial applications, such as anti-plaque, anti-caries, anti-bad breath oral applications, deodorant applications, personal hygiene applications and so on, for which they are included in any suitable carrier medium. Preferred are the capped derivatives, which have been complexed with Ag, Cu, Zn or Sn.

  本发明涉及用于护理人体或其部位的抗微生物化妆品组合物，其中包含组蛋白衍生物或其片段。研究发现，组蛋白或其片段的抗微生物活性可以通过在C端或C端和N端封端和/或与具有抗微生物活性的金属离子络合而显著增强。研究发现，经过这样修饰的组蛋白和组蛋白片段对一系列微生物菌株的活性明显增强，并可用作金属离子的可控递送剂。它们适用于各种抗微生物应用，如抗牙菌斑、抗龋齿、抗口臭口腔应用、除臭应用、个人卫生应用等，可将它们加入任何合适的载体介质中。首选的是与银、铜、锌或锡络合的封端衍生物。