N-甲基伐尼克林 | 328055-92-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 中文名称: N-甲基伐尼克林
• 英文名称: N-Methyl varenicline
• 英文别名: (1R,12S)-14-methyl-5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene
• CAS: 328055-92-1
• 化学式: C₁₄H₁₅N₃
• 分子量: 225.29
• InChiKey: NJHXRPHFYMFVFC-AOOOYVTPSA-N

物化性质

• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINOXALINES
  申请人：Narasimha Rao Mahendranath Rao

  公开号：US20120277433A1

  公开（公告）日：2012-11-01

  The present invention is directed to an improved process for the preparation of substituted quinoxalines by cyclization of the corresponding dianiline in the presence of ion exchange resin.

  本发明涉及一种改进的方法，通过在离子交换树脂存在下，将相应的二胺基苯环烷基化合物环化制备取代的喹啉化合物。
• Preparation of substituted quinoxalines
  申请人：Rainville Philip Joseph

  公开号：US20070185327A1

  公开（公告）日：2007-08-09

  The present invention relates to a new process for the preparation of substituted quinoxalines (I) by cyclization of the corresponding dianiline with 2,3 dihydroxy-1,4-dioxane. In a preferred embodiment, the invention provides a process for the preparation of compounds having the formula wherein Q is a nitrogen protecting group. Compounds of formula III and their derivatives are precursors to certain aryl fused azapolycyclic compounds which exhibit activity as agents for the treatment of neurological and psychological disorders.