5-(aminomethyl)pyridine-2-sulfonamide | 1124321-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(aminomethyl)pyridine-2-sulfonamide
• CAS: 1124321-60-3
• 化学式: C₆H₉N₃O₂S
• 分子量: 187.222
• InChiKey: SKBSXDAOGNSTNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(aminomethyl)pyridine-2-sulfonamide 、 4-chloro-2-methyl-5-nitro-3-phenylpyridine 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以41.5 %的产率得到5-(((2-methyl-5-nitro-3-phenylpyridin-4-yl)amino)methyl)pyridine-2-sulfonamide
  参考文献：
  名称：

  [EN] ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP1) INHIBITORS AND USES THEREOF
  [FR] INHIBITEURS D'ECTONUCLÉOTIDE PYROPHOSPHATASE-PHOSPHODIESTÉRASE 1 (ENPP1) ET LEURS UTILISATIONS

  摘要：

  Described herein are ENPP1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with ENPP1.

  公开号：

  WO2023143520A1

文献信息

• [EN] PHOSPHODIESTERASE INHIBITORS AND USE<br/>[FR] INHIBITEURS DE PHOSPHODIESTÉRASE ET LEUR UTILISATION
  申请人：NANJING ZHENGXIANG PHARMACEUTICALS CO LTD

  公开号：WO2021061803A1

  公开（公告）日：2021-04-01

  The invention provides compounds that may inhibits to ENPP1, and are accordingly useful for treatment disorders related to ENPP1. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent disorders related to ENPP1.

  这项发明提供了可能抑制ENPP1的化合物，因此对治疗与ENPP1相关的疾病非常有用。该发明还提供了含有这些化合物的药物组合物，以及使用这些化合物治疗或预防与ENPP1相关疾病的方法。
• IMIDAZOPYRAZINE COMPOUNDS
  申请人：Macleod Angus

  公开号：US20110166147A1

  公开（公告）日：2011-07-07

  Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

  本发明揭示了一种具有以下公式（I）所表示的化学式的新型咪唑吡唑化合物。该化合物可制备成药物组合物，并可用于预防和治疗病人中的病毒感染，特别是HCV、HRV、Sb和/或CVB。
• IMIDAZO[1,2-A]PYRAZINE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS HEPATITIS
  申请人：Biofocus DPI Limited

  公开号：EP2193131B1

  公开（公告）日：2013-01-30
• PTERIDINE DERIVATIVES AS MODULATORS OF ROR GAMMA
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP3356366B1

  公开（公告）日：2019-08-28
• PHOSPHODIESTERASE INHIBITORS AND USE
  申请人：Nanjing Zhengxiang Pharmaceuticals Co., Ltd.

  公开号：US20220220114A1

  公开（公告）日：2022-07-14

  The invention provides compounds that may inhibits to ENPP1, and are accordingly useful for treatment disorders related to ENPP1. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent disorders related to ENPP1.