1-tert-Butyl-5-nitrobenzimidazol | 35681-33-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-tert-Butyl-5-nitrobenzimidazol
• 英文别名: 1-tert-butyl-5-nitro-1H-benzoimidazole；1-(tert-Butyl)-5-nitro-1H-benzo[d]imidazole；1-tert-butyl-5-nitrobenzimidazole
• CAS: 35681-33-5
• 化学式: C₁₁H₁₃N₃O₂
• 分子量: 219.243
• InChiKey: QXEVVCLRNNHEPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHOD OF TREATING NEURODEGENERATIVE DISEASE
  申请人：Bumcrot David

  公开号：US20110092565A1

  公开（公告）日：2011-04-21

  Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti-SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.
• THERAPEUTIC COMPOSITIONS
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20130144048A1

  公开（公告）日：2013-06-06

  This application relates to therapeutic siRNA agents and methods of making and using the agents.
• MONOMERS AND OLIGONUCLEOTIDES COMPRISING CYCLOADDITION ADDUCT(S)
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20160101189A1

  公开（公告）日：2016-04-14

  The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
• Nonaqueous Electrolyte and Nonaqueous Secondary Battery
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：US20180062213A1

  公开（公告）日：2018-03-01

  The purpose of the present invention is to provide a nonaqueous electrolyte that contains acetonitrile having an excellent balance between viscosity and the dielectric constant and a fluorine-containing inorganic lithium salt, wherein the generation of complex cations comprising a transition metal and acetonitrile is suppressed, excellent load characteristics are exhibited, and increases in internal resistance upon repeated charge/discharge cycles are suppressed; a further purpose of the present invention is to provide a nonaqueous secondary battery. The present invention relates to a nonaqueous electrolyte which contains: a nonaqueous solvent comprising acetonitrile; a fluorine-containing inorganic lithium salt; and a specific nitrogenous cyclic compound typified by benzotriazole.
• US8809516B2
  申请人：——

  公开号：US8809516B2

  公开（公告）日：2014-08-19