4-hydroxy-2-(3,4,5-trifluorophenyl)pyrimidine-5-carboxylic acid ethyl ester | 910053-72-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-hydroxy-2-(3,4,5-trifluorophenyl)pyrimidine-5-carboxylic acid ethyl ester
• 英文别名: Ethyl 3,4-dihydro-4-oxo-2-(3,4,5-trifluorophenyl)-5-pyrimidinecarboxylate；ethyl 6-oxo-2-(3,4,5-trifluorophenyl)-1H-pyrimidine-5-carboxylate
• CAS: 910053-72-4
• 化学式: C₁₃H₉F₃N₂O₃
• 分子量: 298.221
• InChiKey: VJAJUZZHCRUIGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Pyrimidine Carboxylic Acid Derivatives and Use Thereof
  申请人：Woltering Elisabeth

  公开号：US20080194598A1

  公开（公告）日：2008-08-14

  The present application relates to pyrimidinecarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.

  本申请涉及嘧啶羧酸衍生物，其制备方法，其用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管疾病，特别是脂质代谢异常和动脉硬化。