盐酸香豆心安

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 盐酸香豆心安
• 英文名称: 8-[3-(tert-butylamino)-2-hydroxypropoxy]-5-methylchromen-2-one;hydron;chloride
• 化学式: C17H24ClNO4
• 分子量: 341.8
• InChiKey: OQVOZUWFVLLPRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  67.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Ceramic structures for controlled release of biologically active substances
  申请人：Moerck E. Rudi

  公开号：US20060210634A1

  公开（公告）日：2006-09-21

  The present invention provides compositions for controlled drug delivery, dosage forms, and processes for producing dosage forms. In a composition aspect of the present invention, a composition including a drug and a ceramic structure is provided. The ceramic structure has either a hollow portion wherein the drug is included in the hollow portion or is a collection of smaller particles bound together.

  本发明提供了用于控制药物释放的组成物、剂型和制造剂型的过程。在本发明的组成方面，提供了一种包括药物和陶瓷结构的组合物。陶瓷结构具有空心部分，药物包含在空心部分中，或者是由许多小颗粒组成的结合体。
• Novel benzothiazepine and bensothiepine compounds
  申请人：Sasahara Takehiko

  公开号：US20070190041A1

  公开（公告）日：2007-08-16

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:

  提供了一种药物，可用作治疗和预防高脂血症的治疗剂和预防剂，以及一种药物，可用作治疗和预防与胆汁淤积有关的肝脏疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂，以及一种药物，可用作治疗和预防肥胖症、脂肪肝和脂肪性肝炎的治疗剂和预防剂。化合物的苯并噻吩或苯并噻环代表如下式（1A），具有硫酰胺键和季铵取代基：
• CAPSULE
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0580861A1

  公开（公告）日：1994-02-02

  A prolonged-action capsule excellent in adhesion, stability, etc., in the digestive tract. The capsule comprises a polymer excellent in initial adhesion and another polymer excellent in shape retention, both of which are dispersed in a liquid substance, and a physiologically active substance dispersed or dissolved in a liquid substance, and contains water in an amount of 2 % or less as a whole.

  一种在消化道中具有良好粘附性和稳定性的长效胶囊。该胶囊由一种初始粘附性极佳的聚合物和另一种形状保持性极佳的聚合物组成，这两种聚合物都分散在一种液体物质中，还包括一种分散或溶解在液体物质中的生理活性物质，其整体含水量不超过 2%。
• FAST SOLUBLE TABLET
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0627218A1

  公开（公告）日：1994-12-07

  A tablet which dissolves rapidly in the oral cavity and can be prepared in a simple manner without resort to any special preparation technique. The tablet comprises a sugar alcohol or the like as the principal ingredient and is prepared by the wet granulation method wherein a kneaded mixture of the sugar alcohol or the like with a drug is compression molded before drying. This tablet can be prepared merely by modifying partly the conventional tableting method and has a sufficient physicochemical stability.

  一种片剂，可在口腔中快速溶解，制备方法简单，无需采用任何特殊制备技术。这种片剂的主要成分是糖醇或类似物，制备方法是湿法制粒，将糖醇或类似物与药物的揉捏混合物在干燥前压制成型。这种片剂只需部分改变传统的压片方法即可制备，并具有足够的理化稳定性。
• CRYSTALLINE CONDITION DISLOCATING METHOD
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0665009A1

  公开（公告）日：1995-08-02

  An object of this invention is to provide a method of dislocating the crystalline condition of crystalline medicine simply, speedily and homogeneously, and, moreover, in large quantities at once. This invention is directed to a method using an extruder when crystalline medicine in a certain crystalline condition (△ is dislocated to another crystalline condition (○), i.e., when the dislocation of crystalline condition (△->○) is carried out.

  本发明的目的是提供一种简单、快速和均匀地将结晶药物的结晶状态变位的方法，而且是一次性大量变位。本发明针对的是一种使用挤压机将某种结晶状态（△）的结晶药物变位到另一种结晶状态（○）的方法，即结晶状态（△->○）变位的方法。