methyl 2-(hydroxy(8-methyl-2-(p-tolylthio)quinolin-3-yl)methyl)acrylate | 1309389-11-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: methyl 2-(hydroxy(8-methyl-2-(p-tolylthio)quinolin-3-yl)methyl)acrylate
• CAS: 1309389-11-4
• 化学式: C₂₂H₂₁NO₃S
• 分子量: 379.48
• InChiKey: JRGMEYZKBRWPOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.77
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  59.42
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  methyl 2-(hydroxy(8-methyl-2-(p-tolylthio)quinolin-3-yl)methyl)acrylate 在 硫酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以57%的产率得到(E)-methyl 3,12-dimethyl-5H-benzo[7,8]thiocino[2,3-b]quinoline-6-carboxylate sulfate
  参考文献：
  名称：

  First construction of 12H-thiochromeno[2,3-b]quinolines and 5H-benzo[7,8]thiocino-[2,3-b]quinolines via intramolecular Friedel–Crafts reaction of Morita–Baylis–Hillman adducts

  摘要：

  An acid-promoted intramolecular Friedel Crafts reaction of the Morita-Baylis-Hillman adducts 3 derived from 2-arylthioquinolin-3-carbaldehydes 2 was investigated. Interestingly, promoted by sulfuric acid, the substrates with electron-donating groups on the aromatic ring gave six-membered fused-ring 12H-thiochromeno[2,3-b]quinolines 4 with good yields, while those with electron-withdrawing groups afforded eight-membered fused-ring 5H-benzo[7,8]thiocino[2,3-b]quinolines 5 in moderate yields. Using triflic acid instead of sulfuric acid, only products 4 could be obtained under the similar condition. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.039
• 作为产物：
  描述：

  4-甲苯硫酚 在 三乙烯二胺 、 sodium hydride 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 74.0h， 生成 methyl 2-(hydroxy(8-methyl-2-(p-tolylthio)quinolin-3-yl)methyl)acrylate
  参考文献：
  名称：

  First construction of 12H-thiochromeno[2,3-b]quinolines and 5H-benzo[7,8]thiocino-[2,3-b]quinolines via intramolecular Friedel–Crafts reaction of Morita–Baylis–Hillman adducts

  摘要：

  An acid-promoted intramolecular Friedel Crafts reaction of the Morita-Baylis-Hillman adducts 3 derived from 2-arylthioquinolin-3-carbaldehydes 2 was investigated. Interestingly, promoted by sulfuric acid, the substrates with electron-donating groups on the aromatic ring gave six-membered fused-ring 12H-thiochromeno[2,3-b]quinolines 4 with good yields, while those with electron-withdrawing groups afforded eight-membered fused-ring 5H-benzo[7,8]thiocino[2,3-b]quinolines 5 in moderate yields. Using triflic acid instead of sulfuric acid, only products 4 could be obtained under the similar condition. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.039