4-fluoro-2-methyl-1,3-benzoxazol-6-amine | 1643412-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 4-fluoro-2-methyl-1,3-benzoxazol-6-amine
• CAS: 1643412-35-4
• 化学式: C₈H₇FN₂O
• 分子量: 166.155
• InChiKey: FCYIOJFFULKXCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-fluoro-2-methyl-1,3-benzoxazol-6-amine 在 N-甲基咪唑 、 caesium carbonate 、 N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 90.0h， 生成 (R)-N-(4-fluoro-2-methylbenzo[d]oxazol-6-yl)-5-(3-((3-fluoropyrrolidin-1-yl)methyl)azetidin-1-yl)pyrazine-2-carboxamide
  参考文献：
  名称：

  [EN] HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
  [FR] MODULATEURS HTT POUR LE TRAITEMENT DE LA MALADIE DE HUNTINGTON

  摘要：

  以下提供了一些作为HTT调节剂有用的化合物。这些化合物在亨廷顿病的治疗中很有用。

  公开号：

  WO2021231571A1
• 作为产物：
  描述：

  N-(4-fluoro-2-methylbenzo[d]oxazol-6-yl)-1,1-diphenylmethanimine 在 盐酸羟胺 、 sodium acetate 作用下， 生成 4-fluoro-2-methyl-1,3-benzoxazol-6-amine
  参考文献：
  名称：

  [EN] 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME
  [FR] DÉRIVÉS D'ACÉTAMIDO-PHÉNYLTÉTRAZOLE ET LEURS MÉTHODES D'UTILISATION

  摘要：

  The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds of the present disclosure may act as small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded genes, and methods of use of the compounds for modulating splicing and treating related diseases and conditions. The compounds disclosed herein may possess activity toward various genetic pathways and are accordingly useful in methods of treatment of the human or animal body.

  公开号：

  WO2023102231A1

文献信息

• COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20160145270A1

  公开（公告）日：2016-05-26

  The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

  本发明提供了式（I）化合物，其中A、B、X、Y、R1和R2如本文所述，以及其药学上可接受的盐。此外，本发明涉及制备式（I）化合物，包括它们的药物组合物以及它们作为药物的用途。
• HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
  申请人：CHDI Foundation, Inc.

  公开号：US20220409615A1

  公开（公告）日：2022-12-29

  Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
• [EN] COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'UNE AMYOTROPHIE SPINALE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014209841A2

  公开（公告）日：2014-12-31

  The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.