3-[4-(6-Chloro-1H-benzimidazol-2-yl)phenyl]cyclopentanone | 872614-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 3-[4-(6-Chloro-1H-benzimidazol-2-yl)phenyl]cyclopentanone
• 英文别名: 3-[4-(6-chloro-1H-benzimidazol-2-yl)phenyl]cyclopentan-1-one
• CAS: 872614-78-3
• 化学式: C₁₈H₁₅ClN₂O
• 分子量: 310.8
• InChiKey: KUSBMQYXBIWZFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
  申请人：Yang Lihu

  公开号：US20100234409A1

  公开（公告）日：2010-09-16

  Compounds of the formulae (I) and (II): (wherein Q, X, E, G 1 , G 2 , R 2 , R 3 , R 4 , R 5 , R 6 and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.