3-羟基硫杂烷 | 10304-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环丁烷
• 中文名称: 3-羟基硫杂烷
• 英文名称: 3-thietanol
• 英文别名: thietan-3-ol；3-hydroxythietane；Thietanol-(3)
• CAS: 10304-16-2
• 化学式: C₃H₆OS
• mdl: MFCD11848695
• 分子量: 90.146
• InChiKey: YCGJWFCBFZPGJK-UHFFFAOYSA-N

物化性质

• 沸点：
  57 °C
• 密度：
  1.2130 g/cm3
• 溶解度：
  可溶于氯仿、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H312,H315,H319,H332,H335
• 储存条件：
  储存条件：2-8°C，需密封并保持干燥。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Thietan-3-ol
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Thietan-3-ol
CAS number: 10304-16-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C3H6OS
Molecular weight: 90.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, sulfur oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-羟基硫杂烷 在 盐酸 、 aqueous ammonia 、 硫脲 作用下， 以 水 为溶剂， 生成 3-mercaptothietane
  参考文献：
  名称：

  METAL COMPOUND, POLYMERIZABLE COMPOSITION CONTAINING THE SAME, RESIN, METHOD FOR PRODUCING THE RESIN, AND USE OF THE RESIN

  摘要：

  揭示了一种由以下公式（0）表示的金属化合物： 在公式（0）中，A表示噻吩环或含有硫醇基的一价基团；B表示含有杂原子的二价基团；R2表示二价有机基团；n表示M的价；p表示1到n的整数；当A是噻吩环时，M表示镧系元素或钡（Ba）原子，当A是含有硫醇基的一价基团时，M表示镧系元素；Y表示一价无机或有机基团，当n-p不小于2时，多个Y可以各自独立地表示一价无机或有机基团；当n-p不小于2时，多个Y可以彼此连接形成含有M的环。

  公开号：

  US20110136977A1
• 作为产物：
  描述：

  1,3-二氯丙醇 在 三乙基十六烷基氯化铵 sodium sulfide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.0h， 以81%的产率得到3-羟基硫杂烷
  参考文献：
  名称：

  Efficient Syntheses of Thietanes and Thiete 1,1-Dioxide using Phase-Transfer Catalysis

  摘要：

  DOI：

  10.1055/s-1982-29867
• 作为试剂：
  描述：

  2-chloro-4-fluoro-5-[2-methoxy-6-oxo-4-trifluoromethyl-1(6H) pyrimidinyl]-benzoic acid 、 氯化亚砜 、 苯 在 N,N-二甲基甲酰胺 1,4-二氧六环 、 3-羟基硫杂烷 、 吡啶 、 水 、 乙酸乙酯 、 盐酸 、 氯化钠 、 magnesium sulfate 、 silica gel 、 hexane-diethyl ether 作用下， 反应 6.5h， 以In this manner there is obtained thietan-3-yl 2-chloro-4-fluoro-5-[2-methoxy-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate as a colourless oil, 1H-NMR(CDCl3, 400 MHz): 3.37-3.44 (m,2H), 3.57-3.66 (m,2H), 4.03 (s,3H), 5.85 (quintet, 1H), 6.63 (s,1H), 7.42 (d,1H), 7.88 (d,1H)的产率得到thietan-3-yl 2-chloro-4-fluoro-5-[2-methoxy-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate
  参考文献：
  名称：

  Heterocyclic compounds

  摘要：

  该发明涉及公式为##STR1##的新化合物，其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5和R.sup.6的意义如说明书所述，以及其烯醇醚和盐的制造方法，含有这样的化合物作为活性物质的除草剂组合物以及用于控制杂草的活性物质或组合物的使用。该发明还涉及具有除草活性的某些起始材料以及含有这些起始材料的除草剂组合物。

  公开号：

  US04941909A1

文献信息

• ANTI-INFLAMMATORY COMPOUND, AND PREPARATION AND USE THEREOF
  申请人：VivaVision Biotech, Inc.

  公开号：US20200377460A1

  公开（公告）日：2020-12-03

  The present invention provides an anti-inflammatory compound, which is a compound having a structure (I) as shown below: The compound is a target that is important for autoimmune activation, and that has strong inhibitory effect on PDE4 and penetrates the skin easily, and is a new type anti-inflammatory compound that is easily degraded.

  本发明提供一种抗炎化合物，该化合物具有如下所示的结构（I）： 该化合物是一个重要的自身免疫激活靶点，对PDE4具有强烈的抑制作用，易于渗透皮肤，并且是一种易于降解的新型抗炎化合物。
• Pyrolysis of four-membered ring molecules studied by microwave spectroscopy
  作者：M. Rodler、A. Bauder

  DOI：10.1016/0022-2860(83)90175-8

  日期：1983.2

  Abstract Very low pressure vapor phase pyrolysis (flash thermolysis) of four-membered ring compounds was followed by microwave spectroscopic detection of the reaction products. The molecules studied included substituted cyclobutanes, thietanes, oxetane and azetidine. Microwave spectroscopy is well suited not only to observe stable reaction products but also to detect unstable species formed during

  摘要 四元环化合物的极低压汽相热解（闪蒸热解）随后是反应产物的微波光谱检测。研究的分子包括取代的环丁烷、硫杂环丁烷、氧杂环丁烷和氮杂环丁烷。微波光谱不仅非常适合观察稳定的反应产物，还适合检测热解过程中形成的不稳定物质。该调查提供了有关四元环化合物热解过程中典型分解模式的大量信息。此外，还发现了生产一些不稳定分子的新方法，提高了效率。
• INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES
  申请人：Cassayre Jerome Yves

  公开号：US20120238517A1

  公开（公告）日：2012-09-20

  The present invention relates to compounds of formula (I): Wherein A 1 , A 2 , A 3 , A 4 , G 1 , L, Y 1 , Y 2 , Y 3 , Y 4 , R 1 , R 2 , R 3 and R 4 are as defined in claim 1 ; or a salt or N-oxide thereof. Furthermore, the present invention relates to intermediates for preparing compounds of formula (I), to compositions comprising them and to methods of using them to combat and control insect, acarine, nematode and mollusc pests.

  本发明涉及式(I)的化合物：其中A1、A2、A3、A4、G1、L、Y1、Y2、Y3、Y4、R1、R2、R3和R4如权利要求1所定义；或其盐或N-氧化物。此外，本发明涉及制备式(I)化合物的中间体，包含它们的组合物以及使用它们来对抗和控制昆虫、螨虫、线虫和软体动物害虫的方法。
• Quinolone derivatives and antibacterial agents containing the same
  申请人：Wakunaga Seiyaku Kabushiki Kaisha

  公开号：US05245037A1

  公开（公告）日：1993-09-14

  Antibacterial quinolone derivatives represented by the following formula [I] and salts thereof are disclosed. ##STR1## wherein R.sup.1 means a hydrogen atom or a carboxyl-protecting group; R.sup.2 denotes a hydrogen or halogen atom or a hydroxyl, lower alkoxyl, amino, aralkylamino, or mono- or di-(lower alkyl)amino group; A represents an oxygen or sulfur atom or N--R.sup.3 in which R.sup.3 is a hydrogen atom or an amino-protecting group; X is a hydrogen or halogen atom; Y means a nitrogen atom or C--R.sup.4 in which R.sup.4 is a hydrogen or halogen atom or a lower alkyl or lower alkoxyl group; and Z denotes a halogen atom or a substituted or unsubstituted heterocyclic group having at least one nitrogen atom as a hetero atom.

  公开了以下通式[I]表示的抗菌喹诺酮衍生物及其盐： ##STR1## 其中R1表示氢原子或羧基保护基；R2表示氢或卤素原子，或羟基、低级烷氧基、氨基、芳烷基氨基、或单-或二-(低级烷基)氨基；A表示氧或硫原子，或N--R3，其中R3是氢原子或氨基保护基；X是氢或卤素原子；Y表示氮原子或C--R4，其中R4是氢或卤素原子，或低级烷基或低级烷氧基；Z表示卤素原子，或至少有一个氮原子作为杂原子的取代或未取代的杂环基团。
• [EN] INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES<br/>[FR] COMPOSÉS INSECTICIDES À BASE DE DÉRIVÉS ISOXAZOLINE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2011067272A1

  公开（公告）日：2011-06-09

  The present invention relates to compounds of formula (I): Wherein A1, A2, A3, A4, G1, L, Y1, Y2, Y3, Y4, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to intermediates for preparing compounds of formula (I), to compositions comprising them and to methods of using them to combat and control insect, acarine, nematode and mollusc pests.

  本发明涉及式(I)的化合物：其中A1、A2、A3、A4、G1、L、Y1、Y2、Y3、Y4、R1、R2、R3和R4如权利要求1所定义；或其盐或N-氧化物。此外，本发明涉及制备式(I)化合物的中间体，包含它们的组合物以及使用它们来对抗和控制昆虫、螨虫、线虫和软体动物害虫的方法。