2-噻螺并[3.3]庚-6-胺 | 1363381-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环丁烷
• 中文名称: 2-噻螺并[3.3]庚-6-胺
• 英文名称: 2-thiaspiro[3.3]heptan-6-amine
• 英文别名: 2-Thiaspiro[3.3]heptan-6-amine
• CAS: 1363381-30-9
• 化学式: C₆H₁₁NS
• 分子量: 129.226
• InChiKey: SCTLKHGWPOINAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-噻螺并[3.3]庚-6-胺 、 N-(3-(2-(bicyclo[1.1.1]pentan-1-yl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)acetamide 生成 N-(3-(2-(bicyclo[1.1.1]pentan-1-yl)-5-(2-((2,2-dioxido-2-thiaspiro[3.3]heptan-6-yl)amino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)acetamide
  参考文献：
  名称：

  SULFONAMIDO DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS

  摘要：

  The present disclosure provides certain sulfonamido derivatives that are Cyclin-dependent kinase 2 (CDK2) inhibitors of Formula (I): for the treatment of diseases treatable by inhibition of CDK2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  公开号：

  US20230303509A1

文献信息

• NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3033341B1

  公开（公告）日：2017-05-03
• SULFONAMIDO DERIVATIVES AS CYCLIN-DEPENDENT KINASE 2 INHIBITORS
  申请人：NiKang Therapeutics, Inc.

  公开号：US20230303509A1

  公开（公告）日：2023-09-28

  The present disclosure provides certain sulfonamido derivatives that are Cyclin-dependent kinase 2 (CDK2) inhibitors of Formula (I): for the treatment of diseases treatable by inhibition of CDK2. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.