Propane-1-sulfonic acid (2-ethanesulfonylamino-ethyl)-(2R,11bS)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl-amide; compound with (Z)-but-2-enedioic acid | 117145-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Propane-1-sulfonic acid (2-ethanesulfonylamino-ethyl)-(2R,11bS)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl-amide; compound with (Z)-but-2-enedioic acid
• CAS: 117145-28-5
• 化学式: C₄H₄O₄*C₂₀H₃₃N₃O₄S₂
• 分子量: 559.705
• InChiKey: CHHVQLUSFUAWIG-ZKUJQEIMSA-N

反应信息

• 作为产物：
  描述：

  Ethanesulfonic acid {2-[(2R,11bS)-(1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)amino]-ethyl}-amide; hydrochloride 以50.3%的产率得到Propane-1-sulfonic acid (2-ethanesulfonylamino-ethyl)-(2R,11bS)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl-amide; compound with (Z)-but-2-enedioic acid
  参考文献：
  名称：

  Synthesis and .alpha.2-adrenoceptor antagonist activity of some disulfonamidobenzoquinolizines

  摘要：

  A series of disulfonamidobenzo[a]quinolizines were synthesized and evaluated for their alpha 2- and alpha 1-adrenoceptor antagonist activity on the rat vas deferens and anococcygeus muscle, respectively. N-((2 beta,11b alpha)-1,3,4,6,7,11b-Hexahydro-2H-benzo[a]quinolizin-2-yl)-N- [2-[(methylsulfonyl)amino]ethyl]methanesulfonamide (4) and its N-[2-[(methylsulfonyl)amino]ethyl]ethanesulfonamide (22), N-[2-[(ethylsulfonyl)amino]ethyl]ethanesulfonamide (27), and N-[2-[(methylsulfonyl)amino]ethyl]-4-methylbenzenesulfonamide (30) analogues showed 400-fold or greater selectivity in favor of alpha 2- over alpha 1-adrenoceptor blockade.

  DOI：

  10.1021/jm00121a033