5-(1-ethylpropyl)-2-[2-fluoro-6-(trifluoromethyl)phenyl]-3,7-dimethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one | 1079352-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并三嗪类
• 英文名称: 5-(1-ethylpropyl)-2-[2-fluoro-6-(trifluoromethyl)phenyl]-3,7-dimethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
• 英文别名: 2-[2-Fluoro-6-(trifluoromethyl)phenyl]-3,7-dimethyl-5-pentan-3-ylpyrrolo[2,1-f][1,2,4]triazin-4-one
• CAS: 1079352-75-2
• 化学式: C₂₀H₂₁F₄N₃O
• 分子量: 395.4
• InChiKey: ZPSGGAQMOCZNES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• BICYCLIC HETEROCYCLIC COMPOUND
  申请人：Saito Tetsuji

  公开号：US20100137318A1

  公开（公告）日：2010-06-03

  A compound of a formula (I): wherein R 1 represents a C3-10 branched alkyl group which may be substituted; R 2 represents a hydrogen atom or a C1-4 alkyl group which may be substituted; R 3 represents a C1-4 alkyl group which may be substituted or a halogen atom; R 4 represents a C1-4 alkyl group which may be substituted; and ring 1 represents a cyclic group which has planarity and may have a substituent group, a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof, is useful as a medicinal component having CRF antagonistic activity for the prevention and/or treatment of a neuropsychiatric disease, a peripheral organ disease and the like.

  化合物的化学式（I）：其中R1代表一个C3-10支链烷基，可以被取代; R2代表氢原子或C1-4烷基，可以被取代; R3代表C1-4烷基，可以被取代或卤素原子; R4代表C1-4烷基，可以被取代; 环1表示具有平面性且可能具有取代基团的环状基团，其盐，其N-氧化物或其溶剂化物，或其前药，可用作具有CRF拮抗活性的药物成分，用于预防和/或治疗神经精神疾病，外周器官疾病等。
• US8420810B2
  申请人：——

  公开号：US8420810B2

  公开（公告）日：2013-04-16
• [EN] CURABLE COMPOSITION FOR IMPRINT,PATTERNING METHOD AND PATTERN<br/>[FR] COMPOSITION DURCISSABLE POUR IMPRESSION EN CREUX, PROCÉDÉ DE MODELAGE ET MOTIF
  申请人：FUJIFILM CORP

  公开号：WO2010104188A1

  公开（公告）日：2010-09-16

  A curable composition for imprints, which is excellent in patternability and in line edge roughness, is provided. The curable composition for imprints comprises at least one kind of polymerizable monomer (A) and at least one kind of photopolymerization initiator (B). The polymerizable monomer (A) comprises at least two fluorine-containing groups selected from a fluoroalkyl group and a fluoroalkylether group and each of two of the fluorine-containing groups is connected with each other through a linking group having at least two carbon atoms.