N-[(1-methyl-1H-benzotriazol-5-yl)methyl]-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide | 1189584-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: N-[(1-methyl-1H-benzotriazol-5-yl)methyl]-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
• 英文别名: N-[(1-methylbenzotriazol-5-yl)methyl]-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl]acetamide
• CAS: 1189584-57-3
• 化学式: C₁₈H₁₉F₃N₆O
• 分子量: 392.384
• InChiKey: WKUFBHHEIHJLKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• HETEROCYCLIC COMPOUND
  申请人：Mochizuki Michiyo

  公开号：US20110118236A1

  公开（公告）日：2011-05-19

  An object of the present invention is to provide a novel AMPA receptor potentiator. A compound represented by the following formula (I) or a salt thereof: wherein in formula (I) R 1 represents (1) a halogen atom, or (2) cyano group, or the like; Ra and Rb each independently represent a hydrogen atom or C 1-4 alkyl; L represents a bond, or a spacer in which the number of atoms in the main chain is 1 to 8; Ring A represents (1) a non-aromatic carbon ring of 4-8 carbon atoms, or (2) a 4- to 8-membered non-aromatic heterocycle either of which is optionally substituted with 1 or more substituents selected from (a) halogen atoms, and (b) cyano group; and Ar represents a substituted phenyl group, or optionally substituted 5- or 6-membered aromatic heterocyclic group.

  本发明的目的是提供一种新型AMPA受体增强剂。化合物由以下式(I)或其盐所表示：其中在式(I)中，R1表示（1）卤素原子或（2）氰基等；Ra和Rb各自独立地表示氢原子或C1-4烷基；L表示键或主链中原子数为1至8的间隔物；环A表示（1）4-8个碳原子的非芳香碳环，或（2）4-至8个成员的非芳香杂环，其中任一环均可以选择性地用1个或多个取代基所取代，所述取代基选择自(a)卤素原子和(b)氰基；Ar表示取代苯基或可选择性取代的5-或6-成员芳香杂环基。