methyl (Z)-3-chloro-2-(5-(2-fluoro-5-hydroxy-4-methoxyphenyl-amino)-5-oxopent-3-enyl)-4,6-dihydroxybenzoate | 1164274-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (Z)-3-chloro-2-(5-(2-fluoro-5-hydroxy-4-methoxyphenyl-amino)-5-oxopent-3-enyl)-4,6-dihydroxybenzoate
• 英文别名: methyl 3-chloro-2-[(Z)-5-(2-fluoro-5-hydroxy-4-methoxyanilino)-5-oxopent-3-enyl]-4,6-dihydroxybenzoate
• CAS: 1164274-35-4
• 化学式: C₂₀H₁₉ClFNO₇
• 分子量: 439.825
• InChiKey: CUZBKMIPFXNERW-XQRVVYSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  methyl (Z)-4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-(2-fluoro-4-methoxy-5-(tert-butyldimethylsilyloxy)phenylamino)-5-oxopent-3-enyl)benzoate 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 methyl (Z)-3-chloro-2-(5-(2-fluoro-5-hydroxy-4-methoxyphenyl-amino)-5-oxopent-3-enyl)-4,6-dihydroxybenzoate
  参考文献：
  名称：

  Synthesis and Evaluation of Radamide Analogues, A Chimera of Radicicol and Geldanamycin

  摘要：

  Previously, we reported the Hsp90 inhibitory activity of radamide, an open chain amide chimera of geldanamycin and radicicol. Attempts to further expand upon structure-activity relationships for this class of Hsp90 inhibitors led to the preparation of a series of radamide analogues focused on differing tether lengths and quinone mimics. In addition, the cup-shaped conformation adopted by the two natural products when bound to the Hsp90 N-terminal ATP binding pocket suggests that conformationally biased compounds may demonstrate improved binding and inhibition. The preparation and evaluation of radamide analogues with cisltrans alpha,beta-unsaturated amides yielded compounds that exhibit improved antiproliferative activity. In addition, several analogues demonstrated the ability to induce degradation of Hsp90-dependent oncogenic signaling proteins in vitro, a hallmark of Hsp90 N-terminal inhibition.

  DOI：

  10.1021/jo900278g