2-[1-(2-(4-(1,1-dimethylethyl) phenyl)ethyl)piperidin-4-yl]-1H-benzimidazole | 154541-64-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[1-(2-(4-(1,1-dimethylethyl) phenyl)ethyl)piperidin-4-yl]-1H-benzimidazole
• 英文别名: 2-[1-[2-(4-tert-butylphenyl)ethyl]piperidin-4-yl]-1H-benzimidazole
• CAS: 154541-64-7
• 化学式: C₂₄H₃₁N₃
• 分子量: 361.53
• InChiKey: IKDGKKAHPZVKBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  31.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS
  申请人：Lee Chun-Ho

  公开号：US20110009636A1

  公开（公告）日：2011-01-13

  The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2′-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.

  本发明涉及一种制备具有抗组胺活性的2-甲基-2′-苯基丙酸衍生物的工艺，中间体化合物及其用途的制备工艺。根据本发明，在工业规模上可以高产高纯度地制备具有药用价值的2-甲基-2′-苯基丙酸衍生物。
• New piperidine derivatives of benzimidazole as antihistanminic and antiallergic agents
  申请人：FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES)

  公开号：EP0580541A1

  公开（公告）日：1994-01-26

  New piperidine derivatives of benzimidazole of the formula: wherein n is 1 or 2 and R is lower alkyl, lower alkenyl or lower cycloalkyl, or a pharmaceutically acceptable salt thereof, are useful antihistaminic and antiallergic agents.

  式中苯并咪唑的新哌啶衍生物： 其中 n 为 1 或 2，R 为低级烷基、低级烯基或低级环烷基，或其药学上可接受的盐，是有用的抗组胺剂和抗过敏剂。
• Piperidine derivatives of benzimidazole as antihistaminic and antiallergic agents
  申请人：FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES)

  公开号：EP0580541B1

  公开（公告）日：1999-10-06
• PROCESS FOR PREPARATION OF 2-METHYL-2´-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS
  申请人：Yuhan Corporation

  公开号：EP2240464A2

  公开（公告）日：2010-10-20
• US5322850A
  申请人：——

  公开号：US5322850A

  公开（公告）日：1994-06-21