3-cyclohexyl-N1-[(3S)-2-methoxytetrahydrofuran-3-yl]-L-alaninamide | 1032129-91-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 3-cyclohexyl-N1-[(3S)-2-methoxytetrahydrofuran-3-yl]-L-alaninamide
• 英文别名: (2S)-2-amino-3-cyclohexyl-N-[(3S)-2-methoxyoxolan-3-yl]propanamide
• CAS: 1032129-91-1
• 化学式: C₁₄H₂₆N₂O₃
• 分子量: 270.372
• InChiKey: VQVXGZSDCDXFII-VHBIQUBJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel derivatives of 2-hydroxytetrahydrofuran and their use as medicaments
  申请人：Auvin Serge

  公开号：US20050222045A1

  公开（公告）日：2005-10-06

  The invention relates to derivatives of 2-hydroxytetrahydrofuran corresponding to general formula (I) in which A represents the radical, in which R 1 , R 2 , R 4 , R 5 and R 6 represent (in particular), independently, H, a halogen atom, OH, alkyl or alkoxy, R 3 represents H, alkyl or —COR 10 , R 10 representing H, alkyl or alkoxy, and W represents a bond, —CH 2 —CH 2 —, —CH═CH—, —O—, —S— or —NR 11 — in which R 11 represents H or alkyl; X represents —CO—, —Y—CO—, —O—Y—CO— or —NR 12 —Y—CO—, Y represents an alkylene or haloalkylene alkyl, R 12 represents H, alkyl or —COR 13 , R 13 represents H, alkyl, haloalkyl or alkoxy, AA represents, each time that it occurs, a natural or non-natural amino acid; n represents 2 or 3; and finally R represents H, alkyl or —CO—R 19 , R 19 representing alkyl. These compounds have a calpain inhibiting activity and/or an activity which traps the reactive oxygen species and can be used for preparing a medicament intended to treat the inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, cachexia, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.

  该发明涉及与通式（I）相对应的2-羟基四氢呋喃衍生物，其中A代表基团，其中R1、R2、R4、R5和R6代表（特别是），独立地为H、卤素原子、OH、烷基或烷氧基，R3代表H、烷基或—COR10，R10代表H、烷基或烷氧基，W代表键，—CH2— —、—CH═CH—、—O—、—S—或—NR11—，其中R11代表H或烷基；X代表—CO—、—Y—CO—、—O—Y—CO—或—NR12—Y—CO—，Y代表烷基或卤代烷基，R12代表H、烷基或—COR13，R13代表H、烷基、卤代烷基或烷氧基，AA代表，每次出现时，一个天然或非天然氨基酸；n代表2或3；最后R代表H、烷基或—CO—R19，R19代表烷基。这些化合物具有抑制钙蛋白酶活性和/或捕获活性氧物质的活性，可用于制备用于治疗炎症和免疫性疾病、心血管和脑血管疾病、中枢或外周神经系统疾病、虚弱、骨质疏松症、肌肉萎缩症、增殖性疾病、白内障、器官移植后的排斥反应以及自身免疫和病毒性疾病的药物。
• Novel 2-hydroxytetrahydrofurane derivatives and use thereof as medicaments
  申请人：Auvin Serge

  公开号：US20060166893A1

  公开（公告）日：2006-07-27

  A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.

  一种羟基四氢呋喃，其化学式为其中A为，在规范中定义的取代基，具有钙蛋白酶抑制活性和/或捕获反应性氧化物种的活性，可用于治疗炎症和免疫性疾病、心血管和脑血管疾病、中枢或外周神经系统疾病、骨质疏松症、肌肉萎缩症、增生性疾病、白内障、器官移植后的排斥反应以及自身免疫和病毒性疾病。
• NOUVEAUX DERIVES DU 2-HYDROXYTETRAHYDROFURANNE ET LEUR APPLICATION A TITRE DE MEDICAMENTS
  申请人：SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

  公开号：EP1701974A2

  公开（公告）日：2006-09-20
• US7384933B2
  申请人：——

  公开号：US7384933B2

  公开（公告）日：2008-06-10
• US7465721B2
  申请人：——

  公开号：US7465721B2

  公开（公告）日：2008-12-16