2-Butyl-1,4-dichloro-benzene | 138768-48-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Butyl-1,4-dichloro-benzene
• 英文别名: 2-Butyl-1,4-dichlorobenzene
• CAS: 138768-48-6
• 化学式: C₁₀H₁₂Cl₂
• 分子量: 203.111
• InChiKey: AKWXOKCDAFZPCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  正丁基锂 、 alkaline earth salt of/the/ methylsulfuric acid 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 生成 2-Butyl-1,4-dichloro-benzene
  参考文献：
  名称：

  环戊二烯铁介导的加成-脱金属序列将官能化的烷基或炔基引入芳烃

  摘要：

  硝基甲基，氰基甲基和苯基乙炔基阴离子选择性地将邻位添加到含有吸电子基团并与环戊二烯基铁络合的芳烃上。在相似的反应条件下，阴离子如烷基，二氯甲基和三氯甲基以非选择性方式添加。的三氯甲基阴离子的加成在延长反应时间是热力学控制的，并且由于阴离子的大小，元加成产物是有利的。加合物的脱金属导致邻位-硝基甲基化，氰基甲基化或苯基乙炔化的芳烃。对于对称的芳烃配合物，加成-脱金属顺序导致将三氯甲基基团引入芳烃环，从而产生单一产物。从合适的环戊二烯基铁络合物开始的一锅法二烷基芳烃的三氯甲基化可以良好的产率得到β-三氯甲基化的二烷基芳烃。

  DOI：

  10.1016/0022-328x(91)80248-i

文献信息

• ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：SCHAEFER Matthias

  公开号：US20110152290A1

  公开（公告）日：2011-06-23

  The present invention relates to compounds of the formula I, wherein A, Y, Z, R 3 to R 6 , R 20 to R 22 and R 50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA 1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

  本发明涉及式I的化合物，其中A、Y、Z、R3至R6、R20至R22和R50具有所述权利要求中指示的含义，这些化合物是有价值的药物活性化合物。具体来说，它们是内皮分化基因受体2（Edg-2，EDG2）的抑制剂，该受体被溶血磷脂酸（LPA）激活，也称为LPA1受体，可用于治疗动脉粥样硬化、心肌梗塞和心力衰竭等疾病。本发明还涉及制备式I化合物的方法、它们的用途以及包含它们的药物组合物。
• Blend of polyarylene sulfide and wholly aromatic polyester
  申请人：CELANESE CORPORATION

  公开号：EP0044184A2

  公开（公告）日：1982-01-20

  A polymer blend which is capable of exhibiting an anisotropic melt phase, improved processability characteristics and the ability to form molded articles having satisfactory mechanical properties is provided. The polymer blend comprises approximately 5 to approximately 95 percent by weight, based upon the total weight of the blend, of a polyarylene sulfide and approximately 5 to approximately 95 percent by weight, based upon the total weight of the blend, of a melt processable wholly aromatic polyester which is capable of forming an anisotropic melt phase apart from the blend. Blend compositions containing high concentrations of wholly aromatic polyester (i.e., at least 60 percent by weight wholly aromatic polyester) can be used to form fibers and films.

  本发明提供了一种聚合物混合物，该混合物能够显示出各向异性熔融相、改进的加工特性以及形成具有令人满意的机械特性的模塑制品的能力。该聚合物混合物包括按混合物总重量计算的约 5%至约 95%（重量百分比）的聚芳基硫醚和按混合物总重量计算的约 5%至约 95%（重量百分比）的可熔融加工的全芳香族聚酯，该聚酯能够在混合物之外形成各向异性熔融相。含有高浓度全芳香族聚酯（即至少 60% 的全芳香族聚酯重量比）的混合物组合物可用来形成纤维和薄膜。
• Arylene sulfide polymers
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0280274A2

  公开（公告）日：1988-08-31

  Arylene sulfide polymers having a high extrusion rate, e.g. at least about 100g/10 min. are prepared by a process comprising: a) dehy­drating an aqueous admixture of a suitable sulfur source and a cyclic organic amide; b) admixing a dihalo-substituted aromatic compound with the dehydrated mixture to form a polymerization mixture wherein the molar ratio of sulfur source to the cyclic organic amide is about 0.39:1 to about 0.6:1, c) subjecting the polymerization mixture to reaction conditions sufficient to produce the arylene sulfide polymer; and d) recovering the arylene sulfide polymer.

  具有高挤出率（例如至少约 100 克/10 分钟）的亚芳基硫醚聚合物的制备方法包括： a) 将适当硫源和环状有机酰胺的水性混合物脱水； b) 将二卤代芳香族化合物与脱水混合物混合以形成聚合混合物，其中硫源与环状有机酰胺的摩尔比约为 0.39:1至约0.6:1，c)将聚合混合物置于足以产生芳基硫醚聚合物的反应条件下；和d)回收芳基硫醚聚合物。
• Process for preparing arylene sulfide polymers
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0487103A1

  公开（公告）日：1992-05-27

  An arylene sulfide polymer and a process for preparing arylene sulfide polymers by contacting a sulfur source, a cyclic organic amide and a dihaloaromatic compound to form a polymerization mixture, polymerizing the polymerization mixture and recovering the arylene sulfide polymer wherein the process is conducted in the presence of a suitable olefin.

  一种芳基硫醚聚合物和一种制备芳基硫醚聚合物的工艺，其方法是将硫源、环状有机酰胺和二卤代芳香族化合物接触形成聚合混合物，聚合该聚合混合物并回收芳基硫醚聚合物，其中该工艺在有适当烯烃存在的情况下进行。
• Silent markers for petroleum, method of tagging, and method of detection
  申请人：MORTON INTERNATIONAL, INC.

  公开号：EP0509818B1

  公开（公告）日：1995-07-26