6-hydroxy-1,3-dimethyl-5-(2-methyl-4-phenylthiazol-5-yl)pyrimidine-2,4(1H,3H)-dione | 1217509-50-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-hydroxy-1,3-dimethyl-5-(2-methyl-4-phenylthiazol-5-yl)pyrimidine-2,4(1H,3H)-dione
• 英文别名: 6-hydroxy-1,3-dimethyl-5-(2-methyl-4-phenyl-1,3-thiazol-5-yl)pyrimidine-2,4-dione
• CAS: 1217509-50-6
• 化学式: C₁₆H₁₅N₃O₃S
• 分子量: 329.379
• InChiKey: HSOJBAMWNFWPOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,3-dimethyl-5-(2-oxo-2-phenylethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 、 硫代乙酰胺 以 甲醇 为溶剂， 以51%的产率得到6-hydroxy-1,3-dimethyl-5-(2-methyl-4-phenylthiazol-5-yl)pyrimidine-2,4(1H,3H)-dione
  参考文献：
  名称：

  Investigations on 5-(2-aryl-2-oxo-ethylidene)-1,3-dimethylbarbituric and thiobarbituric acids: reactions with thioureas and thioacetamide

  摘要：

  Derivatives of 2-amino- and 2-methylthiazole have been synthesized by the reaction of 5-(2-aryl-2-oxoethylidene)-1,3-dimethylbarbituric and thiobarbituric acids with thioureas and thioacetamide, and also by a one-pot synthesis involving thiourea (or thioacetamide), arylglyoxals, 1,3-dimethyl-barbituric (or thiobarbituric) acids. The mechanisms of the studied reactions are discussed.

  DOI：

  10.1007/s10593-009-0365-9

文献信息

• Multicomponent synthesis of diphenyl-1,3-thiazole-barbituric acid hybrids and their fluorescence property studies
  作者：Alok Mahata、Prabhas Bhaumick、Anoop Kumar Panday、Rahul Yadav、Tasneem Parvin、Lokman H. Choudhury

  DOI：10.1039/d0nj00406e

  日期：——

  arylglyoxal and barbituric acid in water medium was developed. In this second method, in situ thioamides were prepared at room temperature from the reaction of alkyl/aryl nitriles and ammonium sulphide in aqueous medium. Arylglyoxal and barbituric acid were added to the in situ thioamides after neutralizing the reaction medium to provide trisubstituted thiazoles linked with barbituric acid derivatives. Some

  通过两种无催化剂的方法，从容易获得的起始原料中制备了一系列新型的二苯基-1,3-噻唑连接的巴比妥酸杂化物（4）。芳基乙二醛，巴比妥酸和芳基硫酰胺在3-4滴水和液体辅助研磨（LAG）存在下的反应在30分钟内提供了与巴比妥酸部分束缚的相应三取代噻唑。或者，开发了在水介质中涉及芳基腈，硫化铵，芳基乙二醛和巴比妥酸的连续两步一锅法。在第二种方法中，室温下由烷基/芳基腈和硫化铵在水性介质中的反应制备原位硫酰胺。将芳基乙二醛和巴比妥酸添加到中和反应介质后，将其原位加入硫代酰胺中，得到与巴比妥酸衍生物连接的三取代噻唑。我们的一些合成分子在DMSO介质中显示出非常好的量子产率的荧光性质。我们还观察到这些噻唑衍生物的荧光量子产率取决于R 1和R 3的电子给电子/吸电子特征的类型。R 2对调节荧光特性的影响很小。这项工作的主要特点是无催化剂反应，广泛的底物范围，绿色反应条件（在水介质中的液体辅助研磨和室温反应