N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide | 174484-68-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide
• 英文别名: 5-cyano-N-[3-[(1S)-1-[4-hydroxy-6-oxo-2,2-bis(2-phenylethyl)-3H-pyran-5-yl]-2,2-dimethylpropyl]phenyl]pyridine-2-sulfonamide
• CAS: 174484-68-5
• 化学式: C₃₈H₃₉N₃O₅S
• 分子量: 649.811
• InChiKey: JUVYDGRKDAIDJB-DHUJRADRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• SUBSTITUIERTE SPIROALKYLAMINO- UND -ALKOXY-HETEROCYCLEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS SCHÄDLINGSBEKÄMPFUNGSMITTEL UND FUNGIZIDE
  申请人：Hoechst Schering AgrEvo GmbH

  公开号：EP0785934A1

  公开（公告）日：1997-07-30
• PYRANONE COMPOUNDS USEFUL TO MODULATE OMA1 PROTEASE
  申请人：712 North, Inc.

  公开号：US20210246125A1

  公开（公告）日：2021-08-12

  Pyranone compounds are disclosed herein, which were quite surprisingly found as having OMA1 and/or OPA1 modulatory properties. Compounds of present invention may provide useful for the treatment of certain conditions and diseases, which are amenable to OMA1 and/or OPA1-modulatory therapies. Such conditions may include conditions and diseases prevalent in the elderly, such as cancer and Alzheimer's disease. Pharmaceutical compositions comprising compounds of present invention may be combined with other treatments or further comprise other pharmaceutically active ingredients.
• US5852195A
  申请人：——

  公开号：US5852195A

  公开（公告）日：1998-12-22
• US6169181B1
  申请人：——

  公开号：US6169181B1

  公开（公告）日：2001-01-02
• [EN] PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS<br/>[FR] COMPOSES DE PYRANONE UTILES POUR TRAITER DES INFECTIONS A RETROVIRUS
  申请人：——

  公开号：WO1995030670A2

  公开（公告）日：1995-11-16

  [EN] The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R10 and R20 taken together are formulae (III) and (IV).
  [FR] La présente invention concerne des composés de la formule (I) et (II) qui sont des pyran-2-ones, des 5,6-dihydropyran-2-ones, des 4-hydroxy-benzopyran-2-ones, des 4-hydroxycycloalkyl[b]pyran-2-ones, ainsi que leurs dérivés. Ces composés sont utiles pour inhiber un rétrovirus dans une cellule de mammifère infectée par ledit rétrovirus. Dans les formules, R10 et R20 pris ensemble ont les formules (III) et (IV).