4-amino-1-((2R,3S,4R,5R)-5-ethynyl-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidin-2(1H)-one | 1030594-84-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-amino-1-((2R,3S,4R,5R)-5-ethynyl-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidin-2(1H)-one
• 英文别名: 4-amino-1-[(2R,3S,4R,5R)-5-ethynyl-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidin-2-one
• CAS: 1030594-84-3
• 化学式: C₁₁H₁₁F₂N₃O₄
• 分子量: 287.223
• InChiKey: SDBOBWKSDSMJQE-RHXIMWGOSA-N

物化性质

• 沸点：
  467.1±55.0 °C(predicted)
• 密度：
  1.65±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  4-amino-1-((2R,3S,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-3-fluorotetrahydrofuran-2-yl)-5-fluoropyrimidin-2(1H)-one 在 氟化铵 作用下， 以 甲醇 为溶剂， 以78.9 %的产率得到4-amino-1-((2R,3S,4R,5R)-5-ethynyl-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidin-2(1H)-one
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS FOR TREATING DISEASE
  [FR] COMPOSÉS ET MÉTHODES POUR TRAITER UNE MALADIE

  摘要：

  The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.

  公开号：

  WO2023178133A1