3-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[c]pyridine | 83458-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[c]pyridine
• CAS: 83458-56-4
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: WHYJQSWSSKSZSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(2-Oxo-propyl)-cyclohept-1-enecarbaldehyde 在 乙酸铵 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成 3-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[c]pyridine
  参考文献：
  名称：

  芳香族脱核。I.吡啶的合成。

  摘要：

  描述了通过芳香环的修饰从环烷酮制备取代的吡啶。

  DOI：

  10.1016/s0040-4039(00)88421-x

文献信息

• TETRAZOLINONE COMPOUND AND APPLICATIONS THEREOF
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150299146A1

  公开（公告）日：2015-10-22

  The compound represented by formula (1): wherein R 4 and R 5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R 6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R 7 , R 8 , and R 9 each represents a hydrogen atom, a halogen atom, or the like; R 10 represents a C1-C3 alkyl group, or the like; R 13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.

  式(1)所代表的化合物：其中，R4和R5分别表示氢原子、卤素原子或C1-C3烷基；R6表示C1-C4烷基、C3-C6环烷基或类似物；R7、R8和R9分别表示氢原子、卤素原子或类似物；R10表示C1-C3烷基或类似物；R13表示C1-C3烷基或类似物；Q表示苯基或类似物。该化合物对害虫有极好的控制效果。
• TETRAZOLINONE COMPOUND AND USE THEREOF
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP2927218B1

  公开（公告）日：2018-07-04
• Unexpected cyclocotrimerization of α,ω-dialkynes and nitriles to alkynylpyridines catalyzed by arene-solvated cobalt atoms
  作者：Giovanni Vitulli、Sergio Bertozzi、Milo Vignali、Raffaello Lazzaroni、Piero Salvadori

  DOI：10.1016/0022-328x(87)80138-9

  日期：1987.5
• TIUS, M. A.;THURKAUF, A.;TRUESDELL, J. W., TETRAHEDRON LETT., 1982, 23, N 28, 2819-2822
  作者：TIUS, M. A.、THURKAUF, A.、TRUESDELL, J. W.

  DOI：——

  日期：——
• SMALL MOLECULE MODULATORS OF MHC-I
  申请人：RetroVirox, Inc.

  公开号：US20220411419A1

  公开（公告）日：2022-12-29

  The invention disclosed herein are embodiments of compounds capable of treating a viral infection. For example, the compounds are capable of inhibiting viral downmodulation of major histocompatibility complex I (MHC-I), such as by acting as immunomodulators of the immune system to treat, cure or eradicate a viral infection (e.g., HIV infection). More particularly, the present disclosure relates to the use of a heteroaryl compound or salts or analogs thereof, in the treatment of patients infected with a virus. The disclosed compounds may be used alone or in combination with other pharmacologically active agents to treat, cure or eradicate the virus, particularly in patients with persistent, latent viral infection. In some embodiments, the disclosed compounds can be used alone or in combination with other pharmacologically active agents to promote reactivation of viral production in latent cells and eradication of such cells.