diethyl 2-(1-{[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]methyl}cyclopropyl)ethenylphosphonate | 441785-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: diethyl 2-(1-{[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]methyl}cyclopropyl)ethenylphosphonate
• 英文别名: 1-[[1-[(E)-2-diethoxyphosphorylethenyl]cyclopropyl]methyl]-5-methylpyrimidine-2,4-dione
• CAS: 441785-11-1
• 化学式: C₁₅H₂₃N₂O₅P
• 分子量: 342.332
• InChiKey: VEBDVTOSPAUEFT-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES, SALTS THEREOF AND PROCESS FOR THE PREPARATION OF THE SAME<br/>[FR] NOUVEAUX DERIVES DE PHOSPHONATE NUCLEOSIDIQUE ACYCLIQUE, SELS DE CES DERNIERS ET PROCEDE DE PREPARATION DE CES DERNIERS
  申请人：LG CHEM INVESTMENT LTD

  公开号：WO2002057288A1

  公开（公告）日：2002-07-25

  The present invention relates to an acyclic nucleoside phosphonate derivative, which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

  本发明涉及一种无环核苷酸膦酸酯衍生物，其作为抗病毒剂（特别是对乙型肝炎病毒）有用，药学上可接受的盐，立体异构体以及其制备方法。
• Nucleoside phosphonate derivatives useful in the treatment of HIV infections
  申请人：Averett R. Devron

  公开号：US20060052346A1

  公开（公告）日：2006-03-09

  The present invention relates to a method of treating HIV infections by administering a nucleoside phosphonate derivative represented by formula (1).

  本发明涉及通过给予由式（1）表示的核苷酸膦酸衍生物治疗HIV感染的方法。
• Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same
  申请人：——

  公开号：US20040063668A1

  公开（公告）日：2004-04-01

  The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

  本发明涉及一种无环核苷酸膦酸酯衍生物，其可用作抗病毒剂（特别是对乙型肝炎病毒），药学上可接受的盐，立体异构体以及其制备方法。
• NOVEL ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES, SALTS THEREOF AND PROCESS FOR THE PREPARATION OF THE SAME
  申请人：LG Chem Investment, Ltd.

  公开号：EP1358198A1

  公开（公告）日：2003-11-05
• EP1358198A4
  申请人：——

  公开号：EP1358198A4

  公开（公告）日：2008-03-05