2-(4'-Trimethyl-siloxy-phenyl)-ethylisocyanat | 65398-45-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4'-Trimethyl-siloxy-phenyl)-ethylisocyanat
• 英文别名: 2-(4'-Trimethylsiloxyphenyl)ethyl isocyanate；[4-(2-isocyanatoethyl)phenoxy]-trimethylsilane
• CAS: 65398-45-0
• 化学式: C₁₂H₁₇NO₂Si
• 分子量: 235.358
• InChiKey: DORHGRMBOUREIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.78
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 、 三甲基氯硅烷 生成 2-(4'-Trimethyl-siloxy-phenyl)-ethylisocyanat
  参考文献：
  名称：

  EISENHARDT, W. A. ,, JR.;HEDAYA, E.;THEODOROPULOS, S.

  摘要：

  DOI：

文献信息

• Novel isocyanates
  申请人：Union Carbide Corporation

  公开号：US04243605A1

  公开（公告）日：1981-01-06

  Novel isocyanates such as, for example, blocked L-tyrosine methyl ester isocyanate, are reacted with compounds of biological, clinical interest or the like such as, for example, digoxin, to form derivatives receptive to tagging, as by radioliabeling. The tagged derivatives may then be employed to determine the presence of the compound of interest in nanomolar or even picomolar amounts by using clinical analysis techniques such as radioimmunoassay.

  新型异氰酸酯，例如阻塞的L-酪氨酸甲酯异氰酸酯，与生物、临床感兴趣的化合物或类似物反应，例如地高辛，形成易于标记的衍生物，例如通过放射性标记。然后可以使用临床分析技术，如放射免疫测定，来确定感兴趣的化合物的存在，其浓度可以达到纳摩尔甚至皮摩尔水平。
• Halosilyl carbamates
  申请人：United Carbide Corporation

  公开号：US04064151A1

  公开（公告）日：1977-12-20

  Isocyanates are prepared directly from amines in a facile process which involves the reaction with halosilyl compounds to form novel halosilyl carbamates. The isocyanate may then be derived from the carbamate intermediate by gentle heating. In accordance with one aspect of the invention, isocyanates can be formed which contain a further reactive functional moiety, such as hydroxyl, amino, mercapto, nitro, sulfonamido, amido, carboxyl or the like.

  异氰酸酯可以通过一种简单的过程直接从胺中制备，该过程涉及与卤代硅基化合物反应形成新型卤代硅基氨基甲酸酯。然后可以通过轻微加热从氨基甲酸酯中得到异氰酸酯。根据本发明的一个方面，可以形成包含进一步反应性官能团的异氰酸酯，例如羟基、氨基、巯基、硝基、磺酰胺基、酰胺基、羧基等。
• Analytical or clinical derivatives, tagged derivatives and methods of
  申请人：Union Carbide Corporation

  公开号：US04115539A1

  公开（公告）日：1978-09-19

  Novel isocyanates such as, for example, blocked L-tyrosine methyl ester isocyanate, are reacted with compounds of biological, clinical interest or the like such as, for example, digoxin, to form derivatives receptive to tagging, as by radiolabeling. The tagged derivatives may then be employed to determine the presence of the compound of interest in nanomolar or even picomolar amounts by using clinical analysis techniques such as radioimmunoassay.

  新型异氰酸酯，例如受阻的L-酪氨酸甲酯异氰酸酯，与具有生物学、临床兴趣或类似物质的化合物反应，例如地高辛，形成易于标记的衍生物，如通过放射性标记。然后可以使用临床分析技术，如放射免疫测定，来确定感兴趣的化合物的存在，其浓度可以达到纳摩尔甚至皮摩尔级别。
• Method for preparing isocyanates from halosilyl carbamates
  申请人：Union Carbide Corporation

  公开号：US04130576A1

  公开（公告）日：1978-12-19

  Isocyanates are prepared directly from amines in a facile process which involves the reaction with halosilyl compounds to form novel halosilyl carbamates. The isocyanate may then be derived from the carbamate intermediate by gentle heating. In accordance with one aspect of the invention, isocyanates can be formed which contain a further reactive functional moiety, such as hydroxyl, amino, mercapto, nitro, sulfonamido, amido, carboxyl or the like.

  异氰酸酯可以通过简便的方法直接从胺制备，该方法涉及与卤代硅烷化合物反应形成新型卤代硅氨酯。然后可以通过轻微加热从氨酯中间体中得到异氰酸酯。根据该发明的一个方面，可以形成含有进一步反应性官能团的异氰酸酯，例如羟基、氨基、巯基、硝基、磺酰胺基、酰胺基、羧基等。