alpha-Amino acids react with aldehydes in the presence of a cyanide source to form alpha-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable alpha-amino nitrites that are inaccessible by traditional Strecker chemistry.
作者:Deepankar Das、Matthew T. Richers、Longle Ma、Daniel Seidel
DOI:10.1021/ol202957d
日期:2011.12.16
alpha-Amino acids react with aldehydes in the presence of a cyanide source to form alpha-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable alpha-amino nitrites that are inaccessible by traditional Strecker chemistry.