Methyl 5,6,7,8-tetrahydro-6-methyl-7-oxopyrimido[4,5-d]pyrimidine-4-carboxylate | 1237537-47-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Methyl 5,6,7,8-tetrahydro-6-methyl-7-oxopyrimido[4,5-d]pyrimidine-4-carboxylate
• 英文别名: methyl 3-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidine-5-carboxylate
• CAS: 1237537-47-1
• 化学式: C₉H₁₀N₄O₃
• 分子量: 222.203
• InChiKey: LVVQGRMJQYVRJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS
  申请人：Oslob Johan D.

  公开号：US20110059976A1

  公开（公告）日：2011-03-10

  The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: and n, R 1 , R 2 , R 3 , R 4 , L 1 , L 2 , Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.
• US7767687B2
  申请人：——

  公开号：US7767687B2

  公开（公告）日：2010-08-03