4-(4-Bromo-butoxymethyl)-2-heptadecyl-[1,3]dioxolane | 126614-31-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: 4-(4-Bromo-butoxymethyl)-2-heptadecyl-[1,3]dioxolane
• CAS: 126614-31-1
• 化学式: C₂₅H₄₉BrO₃
• 分子量: 477.566
• InChiKey: BPJCJQWOAMKLCZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  4-(4-Bromo-butoxymethyl)-2-heptadecyl-[1,3]dioxolane 、 三甲胺 以 乙腈 为溶剂， 反应 24.0h， 生成 (+/-)-N,N,N-trimethyl-N-<4-<(2-heptadecyl-1,3-dioxolan-4-yl)methoxy>-1-butyl>ammonium bromide
  参考文献：
  名称：

  Synthesis of quaternary amine ether lipids and evaluation of neoplastic cell growth inhibitory properties

  摘要：

  Novel quaternary amine ether lipids have been synthesized and tested for inhibition of neoplastic cell proliferation with the HL-60 promyelocytic leukemia cell line. These compounds contain a positively charged quaternary amine functional group attached either directly to the glycerol backbone or at the end of an alkoxy chain. The biological testing has identified several analogues with activity equivalent to or greater than that exhibited by the reference compound in this assay, ET-18-OMe (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine). Among the most active analogues are compounds 11, [N,N,N-triethyl-3-(hexadecyloxy)-2-ethoxy-1-propylammonium bromide] and 22 [N-[4-[3-(hexadecyloxy)-2-ethoxypropoxy]-1-butyl]pyridinium bromide], which are approximately 3 times as active as the reference standard.

  DOI：

  10.1021/jm00168a042