Diethyl 2-acetyl-1,4-dihydropyrido[4,3-b]quinoxaline-3,3-dicarboxylate | 1226509-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Diethyl 2-acetyl-1,4-dihydropyrido[4,3-b]quinoxaline-3,3-dicarboxylate
• CAS: 1226509-23-4
• 化学式: C₁₉H₂₁N₃O₅
• 分子量: 371.393
• InChiKey: MLXNNEPYKPEEDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  98.7
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,3-双(溴甲基)喹喔啉 、 乙酰氨基丙二酸二乙酯 在 四丁基硫酸氢铵 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 以75%的产率得到Diethyl 2-acetyl-1,4-dihydropyrido[4,3-b]quinoxaline-3,3-dicarboxylate
  参考文献：
  名称：

  Diversity-Oriented Approach to 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Tic) Derivatives Using Diethyl Acetamidomalonate as a Glycine Equivalent: Further Expansion by Suzuki–Miyaura Cross-Coupling Reaction

  摘要：

  Synthesis of diverse 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives and its higher analogues are reported using diethyl acetamidomalonate as a glycine equivalent. In addition, various substituted Tic derivatives are assembled by application of Suzuki-Miyaura cross-coupling reaction as a key step.

  DOI：

  10.3987/com-09-s(s)103

文献信息

• Diversity-Oriented Approach to 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Tic) Derivatives
  作者：Sambasivarao Kotha、Shilpi Misra、Nimita Gopal Krishna、Vijayalakshmi Bandi、Mohammad Saifuddin、Nagaraju Devunuri

  DOI：10.3987/com-15-s(t)16

  日期：——

  A convenient method is reported for synthesizing various 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives and bis-armed acid derivatives by treating dibromo-o-xylylenes precursor with diethyl acetamidomalonate under basic conditions. Suzuki coupling reaction has been to expand this methodology. One of the structure revision of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid into bis-armed amino acid is also reported.