5-(2-Methoxyphenyl)pyrimidin-2-amine | 1111101-90-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(2-Methoxyphenyl)pyrimidin-2-amine
• CAS: 1111101-90-6
• 化学式: C₁₁H₁₁N₃O
• 分子量: 201.228
• InChiKey: UYBBPNVKXFRMMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(2-Methoxyphenyl)pyrimidin-2-amine 、 氯甲酸苯酯 在 吡啶 作用下， 生成 C₁₈H₁₅N₃O₃
  参考文献：
  名称：

  Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists

  摘要：

  Continuing medicinal chemistry studies to identify spiropiperidine-derived NPY Y5 receptor antagonists are described. Aryl urea derivatives of a variety of spiropiperidines were tested for their NPY Y5 receptor binding affinities. Of the spiropiperidines so far examined, spiro[3-oxoisobenzofurane-1(3H),4 '-piperidine] was a useful scaffold for producing orally active NPY Y5 receptor antagonists. Oral administration of 5c significantly inhibited the Y5 agonist-induced food intake in rats with a minimum effective dose of 3 mg/kg. In addition, this compound was efficacious in decreasing body weight in diet-induced obese mice. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.013