ethyl m-methylphenylacetate ethoxycarbonyl hydrazone | 877315-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl m-methylphenylacetate ethoxycarbonyl hydrazone
• 英文别名: ethyl N-ethoxycarbonyl-2-(3-methylphenyl)ethanehydrazonate
• CAS: 877315-79-2
• 化学式: C₁₄H₂₀N₂O₃
• 分子量: 264.324
• InChiKey: GRMMETPWVYJDTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.63
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  59.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  ethyl m-methylphenylacetate ethoxycarbonyl hydrazone 在 一水合肼 作用下， 以 水 为溶剂， 反应 5.0h， 以87%的产率得到3-m-methylbenzyl-4-amino-4,5-dihydro-1H-1,2,4-triazole-5-one
  参考文献：
  名称：

  Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives

  摘要：

  氨基酯盐酸盐 1 已被合成。这些化合物随后被转化为酯乙氧羰酰肼 2，并由此制备出一系列新的 4-氨基-4,5-二氢-1H-1,2,4-三唑-5-酮 3。所有新合成化合物的结构均通过元素分析、红外光谱、1H-NMR 和 13C-NMR 光谱得到证实。

  DOI：

  10.3390/10020376
• 作为产物：
  描述：

  间甲基苯乙腈 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 ethyl m-methylphenylacetate ethoxycarbonyl hydrazone
  参考文献：
  名称：

  Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives

  摘要：

  氨基酯盐酸盐 1 已被合成。这些化合物随后被转化为酯乙氧羰酰肼 2，并由此制备出一系列新的 4-氨基-4,5-二氢-1H-1,2,4-三唑-5-酮 3。所有新合成化合物的结构均通过元素分析、红外光谱、1H-NMR 和 13C-NMR 光谱得到证实。

  DOI：

  10.3390/10020376

文献信息

• Ecofriendly Solventless Synthesis and Reduction Reaction of Some Triazole Compounds and Evaluation of Their Antimicrobial Activity
  作者：Musa Özil、Emre Menteşe、Şengül Alpay Karaoğlu、Bahittin Kahveci

  DOI：10.1080/00397911.2011.632831

  日期：2013.5.3

  Abstract A number of triazole-3-one compounds have been synthesized, and reduction of the carbonyl group in the molecule has been carried out to give a corresponding hydroxyl group that possesses asymmetric carbon atom in good yields and short reaction times. It is ecofriendly because it is produced by straightforward microwave irradiation in the absence of solvent. All newly synthesized compounds

  摘要 已经合成了多种三唑-3-one化合物，并通过还原分子中的羰基得到相应的羟基，该羟基具有不对称碳原子，产率高，反应时间短。它是环保的，因为它是在没有溶剂的情况下通过直接微波辐射生产的。还筛选了所有新合成的化合物的抗微生物活性。抗菌活性研究表明，2d、2i、3c 和 3g-j 对多种微生物显示出良好的活性。补充材料可用于本文。转至出版商的 Synthetic Communications® 在线版以查看免费的补充文件。图形概要
• Microwave-assisted synthesis and antifungal activity of some new 1H-1,2,4-triazole derivatives
  作者：B. Kahveci、M. Özil、E. Menteşe、O. Bekircan、K. Buruk

  DOI：10.1134/s1070428008120178

  日期：2008.12

  A number of 3-aryl-4-arylmethylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized by reaction of the corresponding aromatic aldehydes with 4-amino-3-aryl-1H-1,2,4-triazol-5-ones in anhydrous ethanol under microwave irradiation. The newly synthesized 1H-1,2,4-triazole derivatives were tested for antimicrobial activity. They showed no antibacterial activity but slight mycostatic activity against some Candida species.
• Rapid and Efficient Microwave-Assisted Synthesis of Some New Triazol-3-one Derivatives
  作者：Emre Menteşe、Musa Özil、Şengül Alpay Karaoğlu、Bahittin Kahveci

  DOI：10.1002/jhet.946

  日期：2013.3

  A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new triazol‐3‐ones via microwave heating using a monomode microwave. Compared with the thermal process, the microwave heating induces a dramatic reduction of the reaction time and improvement of the yields. In this study, rapid N‐benzylation and N‐acetylation of triazol‐3‐ones were achieved by microwave irradiation method for the first time. The newly synthesized compounds showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested.