3-苯基哒嗪-4-胺 | 85156-25-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3-苯基哒嗪-4-胺
• 英文名称: 4-amino-3-phenylpyridazine
• 英文别名: 3-Phenylpyridazin-4-amine
• CAS: 85156-25-8
• 化学式: C₁₀H₉N₃
• 分子量: 171.202
• InChiKey: HVMZWEXKGOJZAF-UHFFFAOYSA-N

物化性质

• 熔点：
  146.5-147.5 °C(Solv: benzene (71-43-2))
• 沸点：
  399.1±22.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  3-苯基哒嗪 、 氨基钠 以49%的产率得到
  参考文献：
  名称：

  HARA, HIROSHI;VAN, DER, PLAS, H. C., J. HETEROCYCL. CHEM., 1982, 19, N 6, 1285-1287

  摘要：

  DOI：

文献信息

• Soot Dispersants and Lubricating Oil Compositions Containing Same
  申请人：Bera Tushar K.

  公开号：US20080194438A1

  公开（公告）日：2008-08-14

  Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating, oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.

  发现，连接的芳香化合物在润滑油组合物中作为强效烟尘分散剂；包含这种烟尘分散剂和用于制备烟尘分散剂的前体化合物的润滑油组合物。
• Soot dispersants and lubricating oil compositions containing same
  申请人：Bera K. Tushar

  公开号：US20060189492A1

  公开（公告）日：2006-08-24

  Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.

  链状芳香化合物被发现在润滑油组合物中作为有效的烟尘分散剂；包含这种烟尘分散剂和前体化合物的润滑油组合物，从中可以得到这种烟尘分散剂。
• Lubricating oil compositions
  申请人：Infineum International Limited

  公开号：EP1621602A1

  公开（公告）日：2006-02-01

  Soot induced kinematic viscosity increase of lubricating oil compositions for diesel engines equipped with EGR systems can be ameliorated by selection of viscosity modifier, lubricating oil flow improvers, detergents and/or dispersants.

  可通过选择粘指剂、润滑油流动性改进剂、清洁剂和/或分散剂来改善装有 EGR 系统的柴油发动机润滑油组合物由煤烟引起的运动粘度增加。
• Lubricating Oil Compositions
  申请人：Infineum International Limited

  公开号：EP1661970A1

  公开（公告）日：2006-05-31

  Lubricating oil compositions having a sulfated ash content of no more than 1.0 mass %, which contain a major amount of oil of lubricating viscosity, a minor amount of calcium salicylate detergent, an amount of a magnesium-based detergent providing the lubricating oil composition with at least 200 ppm of magnesium, an amount of a sulfur-containing molybdenum compound providing the lubricating oil composition with at least 20 ppm of molybdenum, and at least one nitrogen-containing dispersant providing the lubricating oil composition with at least 0.9 mass % nitrogen, which compositions provide improved top ring wear protection in internal combustion engines.

  硫酸盐灰分含量不超过 1.0 质量％的润滑油组合物，其中含有大量具有润滑粘度的油、少量水杨酸钙清净剂、一定量的镁基清净剂（使润滑油组合物中的镁含量至少达到 200 ppm）、一定量的含硫钼化合物（使润滑油组合物中的钼含量至少达到 20 ppm）以及至少一种含氮分散剂（使润滑油组合物中的氮含量至少达到 0.9 质量％的氮，这些组合物可改善内燃机顶环的磨损保护。
• Enhancers of cellular cannibalism for use to sensitize tumors to radiation therapy
  申请人：Institut Gustave-Roussy

  公开号：US11471463B2

  公开（公告）日：2022-10-18

  The present invention is drawn to the use of the compounds highlighted in Tables 1 & 2 and analogs thereof, for enhancing IR-mediated cellular cannibalism in cancer cells. Said compounds are herein called “enhancers of IR-mediated cellular cannibalism”. They can be used to enhance tumor immunogenicity and/or to induce a significant protective anticancer immune response in subjects that will receive or that have received a radiotherapy treatment. In other words, said compounds can be used to potentiate a radiotherapy treatment in a subject in need thereof. Said compounds are preferably chosen in the group consisting of: Mebhydroline 1,5-napthalene disulfonate salt, Flurbiprofen, Minaprine dihydrochloride, Myricetin, Digoxin, Digitoxin, Lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450, and VP43.

  本发明涉及表 1 和表 2 所示化合物及其类似物在增强红外介导的癌细胞吞噬功能方面的用途。上述化合物在此称为 "红外介导的细胞吞噬作用增强剂"。它们可用于增强肿瘤免疫原性和/或诱导即将接受或已经接受放疗的受试者产生显著的保护性抗癌免疫反应。换句话说，上述化合物可用于增强需要接受放疗的受试者的放疗效果。所述化合物最好选自以下组别1,5-萘二磺酸甲羟戊酸盐、氟比洛芬、盐酸米那普林、米利西汀、地高辛、地高辛、拉那托苷、LOPA87、VP331、RN-1-026、SG6163F、VP450 和 VP43。