1-(4-氨基丁基)-1H-吡咯-2,5-二酮盐酸盐 | 952292-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(4-氨基丁基)-1H-吡咯-2,5-二酮盐酸盐
• 英文名称: N-(4-aminobutyl) maleimide hydrochloride
• 英文别名: 1-(4-Aminobutyl)-1H-pyrrole-2,5-dione hydrochloride；1-(4-aminobutyl)pyrrole-2,5-dione;hydrochloride
• CAS: 952292-18-1
• 化学式: C₈H₁₂N₂O₂*ClH
• 分子量: 204.656
• InChiKey: GGNLQYNQWRVKDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.07
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  1-(4-氨基丁基)-1H-吡咯-2,5-二酮盐酸盐 、 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.17h， 以15%的产率得到
  参考文献：
  名称：

  PYRAZOLE-TYPE CYANINE DYE

  摘要：

  公开号：

  EP2006289B1

文献信息

• INTRACELLULAR ORGANELLE PEPTIDE TARGETED ENZYME SUBSTRATES
  申请人：Marker Gene Technologies, Inc.

  公开号：US20150219654A1

  公开（公告）日：2015-08-06

  This invention relates to substrates and methods for the visualization of intracellular organelles, such as the lysosome, peroxiosome, nucleus, Endoplasmic Reticulum and Golgi Apparatus, based upon organelle enzyme activity. Such compounds represent a novel combination of chemically distinct enzyme substrates with targeting and detection substrates which are activated by enzyme activity inside target organelles to produce a detectable signal. The organelle targeted enzyme substrates of this invention are designed to provide high fluorescence at lower pH values found in some organelles and can be used for monitoring enzyme activity inside cells at very low concentrations.

  该发明涉及基于细胞器酶活性的底物和方法，用于可视化细胞内细胞器，如溶酶体、过氧化物酶体、细胞核、内质网和高尔基体。这些化合物代表了具有化学上不同的酶底物与靶向和检测底物的新型组合，这些底物受到靶细胞器内的酶活性的激活而产生可检测信号。该发明的细胞器靶向酶底物旨在在一些细胞器中发现的较低pH值下提供高荧光，并可用于监测细胞内酶活性的非常低浓度。
• PYRAZOLE-BASED CYANINE DYE
  申请人：Date Mutsuhiro

  公开号：US20090069546A1

  公开（公告）日：2009-03-12

  Problem Provided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility. Solution The invention provides (1) a compound represented by the following general formula [50] and a salt thereof: [wherein R 1 to R 6 each independently represent a substituted or unsubstituted alkyl group which may have an amide bond; R 7 to R 10 each independently represent alkyl group, alkenyl group, alkynyl group, aryl group, alkoxy group, aryloxy group, alkylthio group, arylthio group, alkylsulfonyl group, arylsulfonyl group, carbamoyl group, sulfamoyl group, ureido group or amino group, those groups being able to have substituents; a group represented by the general formula [2]: —COOR 12 [2] (wherein R 12 represents hydrogen atom, C 1 to C 10 alkyl group, alkali metal atom, organic ammonium ion, ammonium ion or anion); a group represented by the general formula [3]: —SO 3 R 13 [3] (wherein R 13 represents hydrogen atom, alkali metal atom, organic ammonium ion, ammonium ion or anion), halogen atom, aromatic heterocyclic thio group, hydrogen atom, hydroxyl group, cyano group, formyl group, thiol group or nitro group; R 11 represents hydrogen atom, or alkyl group, alkenyl group, alkynyl group or aryl group, those groups being able to have substituents; and n represents an integer of from 0 to 3, provided that any of R 1 and R 2 , R 4 and R 5 , R 1 and R 6 , and R 2 and R 4 may form a bivalent group with a group selected from —O— group, —S— group, —COO— group and groups represented by the general formulae [52] to [54]: (wherein R 50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R 1 to R 11 , along with the bivalent group formed by any of R 1 and R 2 , R 4 and R 5 , R 1 and R 6 , and R 2 and R 4 , has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group; and in the case where said bivalent group is not formed, at least one of R 1 to R 11 has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group]; (2) a labeled compound obtained by subjecting the above compound to direct or indirect binding to a substance to be labeled, and (3) a method for labeling a substance to be labeled, comprising subjecting the above compound to direct or indirect binding to the substance to be labeled.

  问题提供了一种具有吡唑骨架和吲哚骨架的新型靛烯染料衍生物，与传统光学系统相比，在更短的波长区域具有高灵敏度性能，并且具有高水溶性。 解决方案提供了(1)以下一般式[50]及其盐所代表的化合物：[其中R1到R6各自独立地代表取代或未取代的烷基，该烷基可能具有酰胺键；R7到R10各自独立地代表烷基、烯基、炔基、芳基、烷氧基、芳氧基、烷硫基、芳硫基、烷磺酰基、芳基磺酰基、氨基甲酰基、磺酰胺基、脲基或氨基，这些基团能够具有取代基；由以下一般式[2]所代表的基团：—COOR12[2]（其中R12代表氢原子、C1到C10烷基、碱金属离子、有机铵离子、铵离子或阴离子）；由以下一般式[3]所代表的基团：—SO3R13[3]（其中R13代表氢原子、碱金属离子、有机铵离子、铵离子或阴离子）、卤素原子、芳基杂环硫基、氢原子、羟基、氰基、甲酰基、硫醇基或硝基；R11代表氢原子、或烷基、烯基、炔基或芳基，这些基团能够具有取代基；n代表从0到3的整数，前提是R1和R2、R4和R5、R1和R6以及R2和R4中的任何一个可以与选择自—O—基团、—S—基团、—COO—基团和由以下一般式[52]至[54]所代表的基团之一（其中R50代表氢原子、烷基、烯基或芳基，这些基团能够具有取代基）、取代或未取代的烷基烯基，形成双价基团；在形成双价基团的情况下，R1到R11中至少有一个与由R1和R2、R4和R5、R1和R6以及R2和R4中的任何一个形成的双价基团一起，具有由以下一般式[2]和[3]所代表的基团、氨基、羟基、硫醇基或甲酰基；在未形成双价基团的情况下，R1到R11中至少有一个具有由以下一般式[2]和[3]所代表的基团、氨基、羟基、硫醇基或甲酰基]；(2)通过将上述化合物直接或间接结合到待标记物质上而获得的标记化合物，以及(3)用于标记待标记物质的方法，包括将上述化合物直接或间接地结合到待标记物质上。
• Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms
  作者：Jian Li、Jina Sun、Xianglei Zhang、Ruxue Zhang、Qian Wang、Lin Wang、Leike Zhang、Xiong Xie、Chunpu Li、Yu Zhou、Jiang Wang、Gengfu Xiao、Fang Bai、Hong Liu

  DOI：10.1039/d2cc06371a

  日期：——

  A novel strategy to construct maleimide-braced macrocycles has been established. The unique macrocycles exhibited excellent anti-SARS-CoV-2 infection activity via targeting the N protein of SARS-CoV-2.

  一种构建马来酰亚胺支撑的大环的新策略已经建立。这些独特的大环通过针对SARS-CoV-2的N蛋白表现出了出色的抗SARS-CoV-2感染活性。
• Intracellular organelle peptide targeted enzyme substrates
  申请人：Marker Gene Technologies, Inc.

  公开号：US10401361B2

  公开（公告）日：2019-09-03

  This invention relates to substrates and methods for the visualization of intracellular organelles, such as the lysosome, peroxiosome, nucleus, Endoplasmic Reticulum and Golgi Apparatus, based upon organelle enzyme activity. Such compounds represent a novel combination of chemically distinct enzyme substrates with targeting and detection substrates which are activated by enzyme activity inside target organelles to produce a detectable signal. The organelle targeted enzyme substrates of this invention are designed to provide high fluorescence at lower pH values found in some organelles and can be used for monitoring enzyme activity inside cells at very low concentrations.

  本发明涉及基于细胞器酶活性的细胞内细胞器（如溶酶体、过氧化物酶体、细胞核、内质网和高尔基体）可视化底物和方法。这类化合物是化学性质不同的酶底物与靶向和检测底物的新型组合，靶向和检测底物被目标细胞器内的酶活性激活，产生可检测的信号。本发明的细胞器靶向酶底物可在某些细胞器中较低的 pH 值下发出高荧光，可用于监测细胞内极低浓度的酶活性。
• US8921124B2
  申请人：——

  公开号：US8921124B2

  公开（公告）日：2014-12-30