3-苯基甲氧基丙酸苄酯 | 93652-31-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-苯基甲氧基丙酸苄酯
• 英文名称: 3-benzyloxy-propionic acid benzyl ester
• 英文别名: 3-Benzyloxy-propionsaeure-benzylester；Benzyl 3-(benzyloxy)propanoate；benzyl 3-phenylmethoxypropanoate
• CAS: 93652-31-4
• 化学式: C₁₇H₁₈O₃
• mdl: MFCD18430278
• 分子量: 270.328
• InChiKey: TYHIDBILVGODSA-UHFFFAOYSA-N

物化性质

• 沸点：
  222-227 °C(Press: 9 Torr)
• 密度：
  1.0952 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.235
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  β-丙内酯 、 苯甲醇 生成 3-苯基甲氧基丙酸苄酯
  参考文献：
  名称：

  Acylation of Ketones in Dimethyl Sulfoxide¹

  摘要：

  DOI：

  10.1021/jo01055a009

文献信息

• [EN] SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS SPIRO-LACTAMES DES RÉCEPTEURS NMDA ET LEURS UTILISATIONS
  申请人：APTINYX INC

  公开号：WO2018026763A1

  公开（公告）日：2018-02-08

  Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

  揭示了具有调节NMDA受体活性潜力的化合物。这些化合物可用于治疗抑郁症和相关疾病。还公开了口服制剂和其他药学上可接受的化合物给药形式，包括静脉注射制剂。
• PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS
  申请人：Campbell Ian Baxter

  公开号：US20100035926A1

  公开（公告）日：2010-02-11

  The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation.

  本发明提供式(I)的化合物，它们的制备方法，包含这些化合物的制药组合物以及制备这些组合物的方法，中间体，以及将这些化合物用于制造治疗药物，特别是用于治疗炎症的药物。
• NOVEL COMPOUNDS
  申请人：Biggadike Keith

  公开号：US20100120883A1

  公开（公告）日：2010-05-13

  The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.

  本发明提供了式(I)的化合物，其制备方法，包含该化合物的药物组合物及其制备方法，中间体以及利用该化合物制备治疗药物，特别是用于治疗炎症、过敏和/或皮肤疾病。
• Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions
  申请人：BARNETT Heather Anne

  公开号：US20120277279A1

  公开（公告）日：2012-11-01

  The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.

  本发明提供了式（I）的化合物：它们的制备方法，包括这些化合物的制剂以及该制剂的制备方法，中间体以及使用这些化合物制造治疗药物，特别是用于治疗炎症，过敏和/或自身免疫疾病。
• Divergent Cascade Ring‐Expansion Reactions of Acryloyl Imides
  作者：Will E. Orukotan、Kleopas Y. Palate、Balázs Pogrányi、Philipp Bobinski、Ryan G. Epton、Lee Duff、Adrian C. Whitwood、Gideon Grogan、Jason M. Lynam、William P. Unsworth

  DOI：10.1002/chem.202303270

  日期：2024.2.7

  Macrocyclic and medium-sized ring ketones, lactones and lactams can all be made from common acryloyl imide starting materials through divergent, one-pot cascade ring-expansion reactions. A second ring expansion can also be performed following a second iteration of imide formation and alkene functionalisation/ring expansion.

  大环和中环酮、内酯和内酰胺都可以由常见的丙烯酰亚胺起始原料通过发散的一锅级联扩环反应制备。还可以在酰亚胺形成和烯烃官能化/环扩展的第二次迭代之后进行第二次环扩展。