3-苯基磺酰基丙烷酰肼 | 6292-69-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 3-苯基磺酰基丙烷酰肼
• 英文名称: 3-phenylthiopropane hydrazide
• 英文别名: 3-(Phenylthio)propanohydrazide；3-phenylsulfanylpropanehydrazide
• CAS: 6292-69-9
• 化学式: C₉H₁₂N₂OS
• mdl: MFCD11643292
• 分子量: 196.273
• InChiKey: CKHPOCWCCXUBPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 3-phenylthiopropanoate 在 一水合肼 作用下， 反应 2.5h， 以86%的产率得到3-苯基磺酰基丙烷酰肼
  参考文献：
  名称：

  Direct Michael addition to electron-deficient alkenes using diorganyl dichalcogenides (Te/S) and NaBH4/PEG-400

  摘要：

  Nucleophilic species of tellurium and sulfur were generated in situ from the reaction of the respective diorganyl dichalcogenides with NaBH4 in PEG-400 as solvent and selectively added to electron-deficient alkenes. Chalcogenolate anions were directly added at mild conditions by this simple procedure and in all cases furnished the respective Michael adducts in short reaction times and good yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.08.101

文献信息

• Direct Michael addition to electron-deficient alkenes using diorganyl dichalcogenides (Te/S) and NaBH4/PEG-400
  作者：Gelson Perin、Elton L. Borges、Thiago J. Peglow、Eder J. Lenardão

  DOI：10.1016/j.tetlet.2014.08.101

  日期：2014.10

  Nucleophilic species of tellurium and sulfur were generated in situ from the reaction of the respective diorganyl dichalcogenides with NaBH4 in PEG-400 as solvent and selectively added to electron-deficient alkenes. Chalcogenolate anions were directly added at mild conditions by this simple procedure and in all cases furnished the respective Michael adducts in short reaction times and good yields. (C) 2014 Elsevier Ltd. All rights reserved.