2-cyclohexyl-1-tosyl-1H-pyrrole | 1202026-46-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-cyclohexyl-1-tosyl-1H-pyrrole
• CAS: 1202026-46-7
• 化学式: C₁₇H₂₁NO₂S
• 分子量: 303.425
• InChiKey: SUBQMQUDMNXGEW-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-[3-Cyclohexyl-1-(4-methylphenyl)sulfonylaziridin-2-yl]ethynyl-trimethylsilane 在 三苯基膦氯金 、 silver(I) 4-methylbenzenesulfonate 作用下， 以 1,2-二氯乙烷 为溶剂， 以100%的产率得到2-cyclohexyl-1-tosyl-1H-pyrrole
  参考文献：
  名称：

  An efficient and selective synthesis of 2,5-substituted pyrroles by gold-catalysed ring expansion of alkynyl aziridines

  摘要：

  A range of substituted alkynyl aziridines undergo a ring expansion to afford 2,5-substituted pyrroles under gold catalysis. While effective conditions can be generated from other gold sources, a combination of Ph3PAuCl and AgOTs generate a catalyst system that provides extremely clean cycloisomerisation reactions requiring minimal work-up and purification. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.08.040

文献信息

• A facile and regioselective synthesis of 2,5-disubstituted pyrroles via gold-catalyzed cycloisomerization of acetylenylaziridines
  作者：Dong-Dong Chen、Xue-Long Hou、Li-Xin Dai

  DOI：10.1016/j.tetlet.2009.05.091

  日期：2009.12

  Gold-catalyzed cycloisomerization reaction of acetylenylaziridines provides 2,5-disubstituted pyrroles in high yields. The presence of protic species accelerates the reaction rate and improves the yields of pyrrole products.

  乙炔基氮丙啶的金催化的环异构化反应以高收率提供了2,5-二取代的吡咯。质子物种的存在加快了反应速度并提高了吡咯产物的产率。