(rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]-5-(pentafluoroethyl)phenyl}pyrimidin-2-amine | 1427315-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]-5-(pentafluoroethyl)phenyl}pyrimidin-2-amine
• 英文别名: 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]-5-(1,1,2,2,2-pentafluoroethyl)phenyl]pyrimidin-2-amine
• CAS: 1427315-12-5
• 化学式: C₂₁H₁₇F₇N₄O₂S
• 分子量: 522.446
• InChiKey: ISOFTVGEVPDPPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  96.3
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• [EN] DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP<br/>[FR] DÉRIVÉS DE 5-FLUOROPYRIMIDINE DISUBSTITUÉS CONTENANT UN GROUPE SULFOXIMINE
  申请人：BAYER IP GMBH

  公开号：WO2013037894A1

  公开（公告）日：2013-03-21

  The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及含有一种磺氧亚胺基团的二取代5-氟嘧啶衍生物，其一般式（I）如本文所述和定义，并且涉及其制备方法，以及用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病的用途。该发明还涉及在制备上述一般式（I）化合物中有用的中间化合物。
• DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP
  申请人：Lücking Ulrich

  公开号：US20150005329A1

  公开（公告）日：2015-01-01

  The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及一种含有磺酰亚胺基团的二取代5-氟嘧啶衍生物，其通式为(I)，并在此处描述和定义，以及其制备方法，其用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒感染性疾病和/或心血管疾病。本发明还涉及在制备通式(I)化合物中有用的中间体化合物。
• Purification of Aryltriazoles
  申请人：Belter Randolph Kenneth

  公开号：US20150005508A1

  公开（公告）日：2015-01-01

  Impure aryltriazoles such as benzotriazole and tolyltriazole that are contaminated with dark colored imputities can be purified by conversion to an aryltriazole acid salt by treatment with aqueous acid. The aryltriazole acid salt is water soluble whereas the dark colored impurities are not. The aryltriazole acid salt solution is separated from the dark colored impurities and the aryltriazole is recovered by neutralization with base.

  含有深色杂质的不纯芳基三唑，如苯并三唑和甲苯三唑，可通过用水酸处理转化为芳基三唑酸盐来纯化。芳基三唑酸盐是水溶性的，而深色杂质则不是。芳基三唑酸盐溶液与深色杂质分离，然后通过中和处理来回收芳基三唑。
• US9133171B2
  申请人：——

  公开号：US9133171B2

  公开（公告）日：2015-09-15
• US9242942B2
  申请人：——

  公开号：US9242942B2

  公开（公告）日：2016-01-26