trans-[(CH3NH2)2Pt(1-methylthymine-N3)Cl] | 150120-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: trans-[(CH3NH2)2Pt(1-methylthymine-N3)Cl]
• CAS: 150120-54-0
• 化学式: C₈H₁₇ClN₄O₂Pt
• 分子量: 431.782
• InChiKey: KFJREDVTPSRVKQ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  trans-[(CH3NH2)2Pt(1-methylthymine-N3)Cl] 、 sodium perchlorate 、 水 、 7,9-dimethylguanine 在 silver nitrate 作用下， 以 水 为溶剂， 以76%的产率得到trans-[(CH3NH2)2Pt(7,9-dimethylguaninium-N1)(1-methylthymine-N3)]ClO4*0.4H2O
  参考文献：
  名称：

  Hydrogen bonding patterns of 7,9-dimethylguanine and its transplatinum(II) complexes

  摘要：

  Methylation at the N7 position is one of the most frequently naturally occurring modifications of guanosine. This alteration drastically changes the hydrogen bonding and acid-base properties of the guanine nucleobase. Here we show on the example of the model nucleobase 7,9-dimethyl guanine that due to blockage of N7 of the purine ring, new hydrogen bonding patterns occur on the minor groove binding face of this nucleobase involving the ring nitrogen N3 and the exocyclic amino group N2H(2). The free 7,9-dimethylguaninium ion and several transplatinum(II) complexes of the this ligand are presented and discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(02)00962-3

文献信息

• Krizanovic, Olga; Sabat, Michal; Beyerle-Pfnür, Rut, Journal of the American Chemical Society, 1993, vol. 115, # 13, p. 5538 - 5548
  作者：Krizanovic, Olga、Sabat, Michal、Beyerle-Pfnür, Rut、Lippert, Bernhard

  DOI：——

  日期：——