2-(1-benzhydryl-2-tert-butoxycarbonyl-2,3-dihydro-1H-indol-3-yl)-2-benzyl-malonic acid diethyl ester | 1020169-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-benzhydryl-2-tert-butoxycarbonyl-2,3-dihydro-1H-indol-3-yl)-2-benzyl-malonic acid diethyl ester
• CAS: 1020169-93-0
• 化学式: C₄₀H₄₃NO₆
• 分子量: 633.785
• InChiKey: FYNUFQFVVAVROA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-(benzhydrylidene-amino)-3-(2-bromo-phenyl)-4,4-bis-ethoxycarbonyl-5-phenylpentanoic acid tert-butyl ester 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 反应 1.0h， 以82%的产率得到2-(1-benzhydryl-2-tert-butoxycarbonyl-2,3-dihydro-1H-indol-3-yl)-2-benzyl-malonic acid diethyl ester
  参考文献：
  名称：

  Free Radical-Mediated Aryl Amination:  Convergent Two- and Three-Component Couplings to Chiral 2,3-Disubstituted Indolines

  摘要：

  5-exo-trig Cyclization of an aryl radical to the nitrogen of an azomethine is used as the key annulating step in a modular preparation of 2,3-cis- and trans-disubstituted indolines. The precursors are readily prepared by phase-transfer-catalyzed Michael addition of a glycine Schiff base to a variety of acceptors. When the more reactive alkylidene malonate Michael acceptors are implemented, a one-pot three-component coupling is possible. The net result is a convergent [3 + 2] coupling strategy for the construction of highly functionalized indolines, a substructure occurring in numerous biologically active natural products.

  DOI：

  10.1021/jo702523u