L-Fmoc-γ-Acp-OH | 1379827-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: L-Fmoc-γ-Acp-OH
• 英文别名: (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)cyclopentane-1-carboxylic acid
• CAS: 1379827-53-8
• 化学式: C₂₁H₂₁NO₄
• 分子量: 351.402
• InChiKey: BHDMUBZVWRSQOT-KZUDCZAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.78
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.63
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  D-Fmoc-Arg(Pbf)-OH 、 L-Fmoc-γ-Acp-OH 、 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-D-赖氨酸 、 N-[芴甲氧羰基]-D-谷氨酸烯丙基酯 在 N,N-二异丙基乙胺 、 哌啶 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 cyclo-[(D-Arg-L-γ-Acp-D-Glu-L-γ-Acp-D-Lys(Pyr)-L-γ-Acp-D-Lys-)]
  参考文献：
  名称：

  Coupling of Carbon and Peptide Nanotubes

  摘要：

  Two of the main types of nanotubular architectures are the single-walled carbon nanotubes (SWCNTs) and the self-assembling cyclic peptide nanotubes (SCPNs). We here report the preparation of the dual composite resulting from the ordered combination of both tubular motifs. In the resulting architecture, the SWCNTs can act as templates for the assembly of SCPNs that engage the carbon nanotubes noncovalently via pyrene "paddles", each member of the resulting hybrid stabilizing the other in aqueous solution. The particular hybrids obtained in the present study formed highly ordered oriented arrays and display complementary properties such as electrical conductivity. Furthermore, a self-sorting of the cyclic peptides toward semiconducting rather than metallic SWCNTs is also observed in the aqueous dispersions. It is envisaged that a broad range of exploitable properties may be achieved and/or controlled by varying the cyclic peptide components of similar SWCNT/SCPN hybrids.

  DOI：

  10.1021/ja410901r