4-chloro-3-methylthio-pyridine | 151373-08-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-chloro-3-methylthio-pyridine
• 英文别名: 4-Chloro-3-methylsulfanylpyridine
• CAS: 151373-08-9
• 化学式: C₆H₆ClNS
• 分子量: 159.639
• InChiKey: PVSFTPCUGFVQLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  吗啉 、 4-chloro-3-methylthio-pyridine 反应 6.0h， 以95%的产率得到N-(3-methylthio-pyrid-4-yl)-morpholine
  参考文献：
  名称：

  The reaction of some Halogenated Pyridine Thioethers and sulphones with carbon disulphide

  摘要：

  Dithiocarboxylation of some halogenated pyridine sulphones with carbon disulphide and sodium hydride leads to the formation of thiomethyl derivatives via Smiles rearrangement of the inititially produced dianion, fragmentation and subsequent methylation. In one instance the pyridino[2,3-b]-1,4-dithiine 7 was obtained. The thioether 2d was also converted into a thiomethyl derivative when subjected to the same reaction sequence.

  DOI：

  10.1002/prac.19933350309
• 作为产物：
  描述：

  3-氟吡啶 N-氧化物 在 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.17h， 生成 4-chloro-3-methylthio-pyridine
  参考文献：
  名称：

  The reaction of some Halogenated Pyridine Thioethers and sulphones with carbon disulphide

  摘要：

  Dithiocarboxylation of some halogenated pyridine sulphones with carbon disulphide and sodium hydride leads to the formation of thiomethyl derivatives via Smiles rearrangement of the inititially produced dianion, fragmentation and subsequent methylation. In one instance the pyridino[2,3-b]-1,4-dithiine 7 was obtained. The thioether 2d was also converted into a thiomethyl derivative when subjected to the same reaction sequence.

  DOI：

  10.1002/prac.19933350309