6-(3-chloro-phenyl)-3-(2-hydroxy-phenyl)-3,4-dihydro-1H-pyrimidin-2-one | 36945-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(3-chloro-phenyl)-3-(2-hydroxy-phenyl)-3,4-dihydro-1H-pyrimidin-2-one
• 英文别名: 1-(2'-hydroxyphenyl)-4-(3''-chlorophenyl)-1,2,3,6-tetrahydropyrimidine-2-one；6-(3-Chlorophenyl)-3-(2-hydroxyphenyl)-1,4-dihydropyrimidin-2-one
• CAS: 36945-82-1
• 化学式: C₁₆H₁₃ClN₂O₂
• 分子量: 300.744
• InChiKey: ULPONFIKGDJSFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Novel compounds and their uses
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20040067970A1

  公开（公告）日：2004-04-08

  Use of a compound according to Formula [I]: 1 or a salt thereof to produce a cooling sensation, wherein R 1 and R 2 are independently selected from hydrogen or halogen atoms; hydroxy, cyano, nitro, mercapto, carbonyl, sulfone and carboxy groups: or optionally substituted alkyl, alkenyl, alkoxy, alkylthio, aryl, aryloxy, arylthio, amino, siloxy, ester and heterocyclic groups, with the proviso that when R 1 is 2-hydroxyphenyl, R 2 is other than 3-nitrophenyl.

  使用式[I]中的化合物或其盐可产生冷却感，其中R1和R2分别选择自氢原子或卤素原子；羟基、氰基、硝基、巯基、羰基、砜基和羧基基团；或者是选择性取代的烷基、烯基、烷氧基、烷硫基、芳基、芳氧基、芳硫基、氨基、硅氧基、酯基和杂环基团，但是当R1为2-羟基苯基时，R2不能为3-硝基苯基。
• Combination compositions and their use in methods for treating obesity and obesity-related disorders
  申请人：Helmholtz Zentrum Munchen—Deutsches Forschungszentrum fur Gesundheit Und Umwelt (GMBH)

  公开号：US10568852B2

  公开（公告）日：2020-02-25

  The present invention relates to compositions comprising at least two different active compounds and the use of such combination compositions in medicine, in particular in methods for treating obesity and obesity-related disorders and/or in methods for inhibiting weight gain.

  本发明涉及包含至少两种不同活性化合物的组合物，以及这种组合物在医学中的应用，特别是在治疗肥胖和肥胖相关疾病的方法和/或抑制体重增加的方法中的应用。
• TETRAHYDROPYRIMIDINE-2-ONE DERIVATIVES AND THEIR USES
  申请人：Unilever PLC

  公开号：EP1546114B1

  公开（公告）日：2015-09-30
• COMBINATION OF TRPM8-AGONIST AND NACHR-AGONIST FOR TREATMENT OF OBESITY AND RELATED DISORDERS AND FOR WEIGHT REDUCTION
  申请人：Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

  公开号：EP3297676A2

  公开（公告）日：2018-03-28
• Composition
  申请人：Freunscht Peter

  公开号：US20060280697A1

  公开（公告）日：2006-12-14

  An oral care composition, comprising: a therapeutically effective amount of a cooling compound having the structure of Formula [I]: or a salt thereof to produce a cooling sensation, wherein R 1 and R 2 are independently selected from hydrogen or halogen atoms; hydroxy, cyano, nitro, mercapto, carbonyl, sulfone and carboxy groups; or optionally substituted alkyl, alkenyl, alkoxy, alkylthio, aryl, aryloxy, arylthio, amino, siloxy, ester and heterocyclic groups, characterised by an oil soluble agent for solubilising or emulsifying the cooling compound.