(R)-2-Benzyl-4-(R)-1,2,3,4-tetrahydro-isoquinolin-3-yl-butyric acid | 882172-41-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (R)-2-Benzyl-4-(R)-1,2,3,4-tetrahydro-isoquinolin-3-yl-butyric acid
• CAS: 882172-41-0
• 化学式: C₂₀H₂₃NO₂
• 分子量: 309.408
• InChiKey: YLECDBJPJQHACE-IEBWSBKVSA-N

反应信息

• 作为反应物：
  描述：

  (R)-2-Benzyl-4-(R)-1,2,3,4-tetrahydro-isoquinolin-3-yl-butyric acid 在 Pd-BaSO₄ N-甲基吗啉 、 氢气 、 1-羟基苯并三唑 、 溶剂黄146 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 37.0h， 生成 N-{3-[(2S,4R)-4-Benzyloxy-1-((R)-2-benzyl-4-(R)-1,2,3,4-tetrahydro-isoquinolin-3-yl-butyryl)-pyrrolidin-2-yl]-propyl}-guanidine
  参考文献：
  名称：

  Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

  摘要：

  The first synthesis of Tic-D-Phe Psi[CH2-CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrated by the synthesis of peptidomimetic 7 and non-peptidic ligand 27. Both compounds displayed significant binding and agonist potency at the MC4R. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.005
• 作为产物：
  描述：

  (3R,11aR)-3-Benzyl-1,2,3,6,11,11a-hexahydro-pyrido[1,2-b]isoquinolin-4-one 在 盐酸 作用下， 反应 24.0h， 以100%的产率得到(R)-2-Benzyl-4-(R)-1,2,3,4-tetrahydro-isoquinolin-3-yl-butyric acid
  参考文献：
  名称：

  Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

  摘要：

  The first synthesis of Tic-D-Phe Psi[CH2-CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrated by the synthesis of peptidomimetic 7 and non-peptidic ligand 27. Both compounds displayed significant binding and agonist potency at the MC4R. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.005