MAG-DPA | 1024694-51-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: MAG-DPA
• 英文别名: 2,3-dihydroxypropyl (7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaenoate
• CAS: 1024694-51-6
• 化学式: C₂₅H₄₀O₄
• 分子量: 404.59
• InChiKey: IDSLCYURGAOTOA-JLNKQSITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  MAG-DPA 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  POLYUNSATURATED FATTY ACID MONOGLYCERIDES, DERIVATIVES, AND USES THEREOF

  摘要：

  提供了化合物的公式(I)：其中X1为O、NH或S；X2为O、NH或S；X3为O、NH或S；而R、R1、T1和T2可以代表不同的实体。这些化合物可以用于预防、缓解或治疗各种疾病，如心脏病、呼吸系统疾病、治疗炎症异常、代谢紊乱或糖尿病等。

  公开号：

  US20150119591A1
• 作为产物：
  描述：

  (2,2-dimethyl-1,3-dioxolan-4-yl)methyl (7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaenoate 在 acidic resin 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 MAG-DPA
  参考文献：
  名称：

  WO2008/98375

  摘要：

  公开号：

文献信息

• Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof
  申请人：SCF PHARMA INC.

  公开号：US10716776B2

  公开（公告）日：2020-07-21

  There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful for increasing the life span of a subject; for increasing the disability-free life expectancy, for slowing down the ageing process of a subject; for increasing the mitochondrial OXPHOS of a subject; for decreasing the mitochondrial LEAK of a subject; for increasing the mitochondrial RCR or COUPLING EFFICIENCY of a subject; and for optimizing the mitochondrial functions of a subject. These compounds and compositions comprise at least one compound chosen from

  本文提供了包含多不饱和脂肪酸单甘酯及其衍生物的各种化合物和组合物。这些化合物和组合物可用于延长受试者的寿命；延长受试者的无残疾预期寿命；延缓受试者的衰老过程；增加受试者的线粒体氧合；减少受试者的线粒体渗漏；增加受试者的线粒体RCR或COUPLING EFFICIENCY；以及优化受试者的线粒体功能。这些化合物和组合物包含至少一种选自以下的化合物
• Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity
  作者：Hyeun Wook Chang、Kyoung Hwa Jang、Doohyun Lee、Hee Ryong Kang、Tae-Yoon Kim、Bong Ho Lee、Byoung Wook Choi、Sanghee Kim、Jongheon Shin

  DOI：10.1016/j.bmcl.2008.05.008

  日期：2008.6

  Polyunsaturated fatty acid-derived monoglycerides were characterized from the marine brown alga Sargassum sagamianum, collected from Jeju Island, Korea. A new compound of this structural class was isolated and determined to be 1-octadecatetraenoyl glycerol, by combined spectroscopic methods. Based on the structures and bioactivity of these compounds, a series of monoglycerides were synthesized using glycerol and various fatty acids. Several compounds exhibited moderate to significant inhibition of phospholipase A(2) and cyclooxygenase-2. (C) 2008 Elsevier Ltd. All rights reserved.
• WO2008/113177
  申请人：——

  公开号：——

  公开（公告）日：——
• COMPOSITIONS COMPRISING POLYUNSATURATED FATTY ACID MONOGLYCERIDES OR DERIVATIVES THEREOF AND USES THEREOF
  申请人：FORTIN Samuel

  公开号：US20090291102A1

  公开（公告）日：2009-11-26

  There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful as cancer chemopreventive agents. They can also be useful for enhancing solubility of various active agents and enhancing their bioavailability.
• COMPOSITIONS COMPRISING POLYUNSATURATED FATTY ACID MONOGLYCERIDES, DERIVATIVES THEREOF AND USES THEREOF
  申请人：FORTIN Samuel

  公开号：US20120208884A1

  公开（公告）日：2012-08-16

  There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful as cancer chemopreventive agents. They can also be useful for enhancing solubility of various active agents and enhancing their bioavailability.