2,6-di-acetylamino-4-iodo-pyridine | 662164-80-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,6-di-acetylamino-4-iodo-pyridine
• 英文别名: 2,6-Diacetylamino-4-iodopyridine；N-(6-acetamido-4-iodopyridin-2-yl)acetamide
• CAS: 662164-80-9
• 化学式: C₉H₁₀IN₃O₂
• 分子量: 319.102
• InChiKey: XKTAERFMEMWENG-UHFFFAOYSA-N

物化性质

• 沸点：
  556.5±50.0 °C(Predicted)
• 密度：
  1.867±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-di-acetylamino-4-iodo-pyridine 在 chromium(VI) oxide 、 zinc trifluoromethanesulfonate 、 溶剂黄146 、 三乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 56.0h， 生成 1,8-di[(2,6-diacetylaminopyridin-4-yl)ethynyl]-anthraquinone
  参考文献：
  名称：

  迈向人工氧化DNA光解酶

  摘要：

  报道了用于选择性分子识别顺式，顺式环丁烷嘧啶二聚体的两个屈光受体的设计，合成，结构和结合亲和力。该设计基于两个2,6-二（乙酰氨基）吡啶识别单元，它们通过三键共价连接至蒽醌功能性间隔基单元。收敛合成使用了涉及锌转金属的修饰的Sonogashira反应作为关键步骤。受体之一的晶体结构揭示了一种超分子一维聚合物，该聚合物具有较强的相互作用，该相互作用由形状自互补，π堆积和相邻分子之间的氢键介导。相邻链之间的氢键强制平行取向，从而导致高极性化合物的非中心对称晶体结构。受体的缔合常数为K a = 1.0×10 3 M - 1，具有顺式，顺式嘧啶二聚体，而反式，顺式异构体的结合力弱约1个数量级。

  DOI：

  10.1021/jo0354600
• 作为产物：
  描述：

  乙酸酐 、 2,6-di-tert-butoxycarbonylamino-4-iodo-pyridine 在 苯甲醚 、 三氟乙酸 、 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 2,6-di-acetylamino-4-iodo-pyridine
  参考文献：
  名称：

  迈向人工氧化DNA光解酶

  摘要：

  报道了用于选择性分子识别顺式，顺式环丁烷嘧啶二聚体的两个屈光受体的设计，合成，结构和结合亲和力。该设计基于两个2,6-二（乙酰氨基）吡啶识别单元，它们通过三键共价连接至蒽醌功能性间隔基单元。收敛合成使用了涉及锌转金属的修饰的Sonogashira反应作为关键步骤。受体之一的晶体结构揭示了一种超分子一维聚合物，该聚合物具有较强的相互作用，该相互作用由形状自互补，π堆积和相邻分子之间的氢键介导。相邻链之间的氢键强制平行取向，从而导致高极性化合物的非中心对称晶体结构。受体的缔合常数为K a = 1.0×10 3 M - 1，具有顺式，顺式嘧啶二聚体，而反式，顺式异构体的结合力弱约1个数量级。

  DOI：

  10.1021/jo0354600

文献信息

• NANOPORE BASED SEQUENCER
  申请人：ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

  公开号：US20170204066A1

  公开（公告）日：2017-07-20

  The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

  本发明涉及用于识别生物聚合物（例如DNA链）的系统、设备和方法，当它们通过像碳纳米管纳孔这样的狭窄通道时。更具体地说，本发明涉及这种系统、设备和方法，其中生物聚合物的新穿过部分在纳米管纳孔和第二电极之间形成临时电路，第二电极也可能是一个纳米管。此外，本发明涉及这种系统、设备和方法，其中通道配备有一个功能化单元，该单元与生物聚合物的新穿过部分一起形成临时电路，可用于表征生物聚合物的部分。
• Trans-base tunnel reader for sequencing
  申请人：ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

  公开号：US10442771B2

  公开（公告）日：2019-10-15

  The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

  本发明涉及用于识别生物聚合物（如 DNA 链）的系统、装置和方法，当它们通过诸如碳纳米管纳米孔的收缩时。更具体地说，本发明涉及这样的系统、装置和方法，其中新转移的生物聚合物部分在纳米管纳米孔和第二电极（也可以是纳米管）之间形成临时电路。此外，本发明还涉及这样的系统、装置和方法，其中的收缩装置具有功能化单元，该单元与生物聚合物的新移位部分一起形成临时电路，可用于表征生物聚合物的该部分。
• Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer
  申请人：Lindsay Stuart

  公开号：US20110120868A1

  公开（公告）日：2011-05-26

  The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
• Nanopore and Carbon Nanotube Based DNA Sequencer
  申请人：Nuckolls Colin

  公开号：US20110168562A1

  公开（公告）日：2011-07-14

  The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.
• Nanopore and Carbon Nanotube Based Dna Sequencer and A Serial Recognition Elements
  申请人：Reinhart Kevin

  公开号：US20130186757A1

  公开（公告）日：2013-07-25

  The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.