5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)- | 71809-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)-
• 英文别名: 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS: 71809-37-5
• 化学式: C₂₄H₃₃N₉O₆S₃
• 分子量: 639.8
• InChiKey: LJAJUDBKHHSMDY-VQIMIIECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  42
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  267
• 氢给体数：
  2
• 氢受体数：
  15

文献信息

• Parenteral combination therapy for infective conditions
  申请人：——

  公开号：US20030219461A1

  公开（公告）日：2003-11-27

  A method is provided for treatment or prevention of an infective condition having an inflammatory component. The method comprises parenteral administration of an antibacterial agent in an antibacterially effective amount, in combination therapy with a selective cyclooxygenase-2 inhibitor in an amount sufficient to provide systemic anti-inflammatory activity. Also provided is a parenterally deliverable pharmaceutical composition comprising an antibacterial agent and a selective COX-2 inhibitor together with one or more excipients.

  提供了一种治疗或预防具有炎症成分的感染性疾病的方法。该方法包括抗菌有效量的抗菌剂与选择性环氧化酶-2 抑制剂的肠外给药，选择性环氧化酶-2 抑制剂的量足以提供全身抗炎活性。此外，还提供了一种肠外给药的药物组合物，其中包含一种抗菌剂和一种选择性 COX-2 抑制剂以及一种或多种赋形剂。
• Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
  申请人：——

  公开号：US20040033938A1

  公开（公告）日：2004-02-19

  A method is provided for treatment of an infective condition in an udder of a milk producing animal. The method comprises intramammary administration of an antibacterial agent in combination therapy with a selective COX-2 inhibitor in therapeutically effective amounts of each. Also provided is a pharmaceutical composition comprising an antibacterial agent and a selective COX-2 inhibitor, together with one or more excipients, in a dosage form suitable for intramammary administration to a milk producing animal.

  提供了一种治疗产奶动物乳房感染病症的方法。该方法包括在乳房内施用抗菌剂和选择性 COX-2 抑制剂，每种抗菌剂和选择性 COX-2 抑制剂的用量均为治疗有效量。本发明还提供了一种药物组合物，该组合物包含抗菌剂和选择性 COX-2 抑制剂，以及一种或多种赋形剂，其剂型适于产乳动物乳房内给药。
• Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
  申请人：——

  公开号：US20040214753A1

  公开（公告）日：2004-10-28

  A method is provided for treatment of an infective condition in a fluid-containing organ having a natural exterior orifice, such as the udder of a milk producing animal or an ear. The method comprises administering an antibacterial agent to the organ via the exterior orifice and administering in combination therapy with the antibacterial agent a second agent that is an anti-inflammatory agent, an analgesic and/or an antipyretic. The antibacterial agent and, optionally, the second agent, are administered as a pharmaceutical composition further comprising a vehicle that comprises an amphipathic oil that is water dispersible and ethanol insoluble, microcrystalline wax and a pharmaceutically acceptable non-aqueous carrier. Also provided is such a composition comprising the antibacterial agent and the second agent. The composition is readily dispersible in the fluid of the fluid-containing

  本发明提供了一种方法，用于治疗具有天然外部孔口的含液器官（如产奶动物的乳房或耳朵）的感染病症。该方法包括通过外部孔口向器官施用抗菌剂，并与抗菌剂联合施用第二种抗炎剂、镇痛剂和/或解热剂。抗菌剂和第二种药剂以药物组合物的形式给药，该药物组合物还包括一种载体，该载体由水分散且不溶于乙醇的两性油、微晶蜡和药学上可接受的非水性载体组成。还提供了这样一种包含抗菌剂和第二药剂的组合物。该组合物易于分散在含流体的流体中。
• Dispersible formulation of an anti-inflammatory agent
  申请人：——

  公开号：US20040235803A1

  公开（公告）日：2004-11-25

  A method is provided for treatment of an inflammatory condition in a fluid-containing organ having a natural exterior orifice, such as the udder of a milk producing animal or an ear. The method comprises administering, to the organ via the exterior orifice, a pharmaceutical composition comprising an anti-inflammatory agent and a vehicle that comprises an amphipathic oil that is water dispersible and ethanol insoluble, microcrystalline wax and a pharmaceutically acceptable non-aqueous carrier. Also provided is such a composition comprising the anti-inflammatory agent. The composition is readily dispersible in the fluid of the fluid-containing organ.

  本发明提供了一种方法，用于治疗具有天然外部孔口的含液器官（如产奶动物的乳房或耳朵）的炎症。该方法包括通过外部孔口向器官施用药物组合物，该组合物包括抗炎剂和载体，载体包括可在水中分散且不溶于乙醇的两性油、微晶蜡和药学上可接受的非水性载体。还提供了这样一种包含消炎剂的组合物。该组合物易于分散在含液器官的液体中。
• Cephalosporin derivatives
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0155103B1

  公开（公告）日：1989-10-25