3-溴-2,6-二氯苯甲酸 | 80257-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-溴-2,6-二氯苯甲酸
• 英文名称: 3-bromo-2,6-dichlorobenzoic acid
• CAS: 80257-12-1
• 化学式: C₇H₃BrCl₂O₂
• 分子量: 269.91
• InChiKey: UPXIKFYPSUMMSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• [EN] INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE L'INTÉGRINE ALPHA 2 BÊTA 1 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2021222789A1

  公开（公告）日：2021-11-04

  Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.

  本公开的内容包括阿尔法2贝塔1整合素的抑制剂以及使用这些抑制剂的方法。
• 6-(Poly-substituted aryl)-4-aminopicolinates and their use as herbicides
  申请人：Balko W. Terry

  公开号：US20070179060A1

  公开（公告）日：2007-08-02

  4-Aminopicolinic acids having tri- and tetra-substituted aryl substituents in the 6-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

  在6位具有三取代和四取代芳基取代基的4-氨基吡啶酸及其胺和酸衍生物是一类高效除草剂，展示出广泛的杂草控制谱。
• Inhibitors of alpha4 mediated cell adhesion
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US20030191118A1

  公开（公告）日：2003-10-09

  The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, —O— -(lower alkylene)-, etc.; n is 0, 1 or 2; Z is oxygen or sulfur; W is oxygen, sulfur, —CH═CH—, —NH— or —N═CH—; R 1 , R 2 and R 3 are the same or different and are hydrogen, halogen, hydroxyl, a substituted or unsubstituted lower alkyl gorup, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, etc.; R 4 is tetrazolyl, carboxyl group, amide or ester; R 5 is hydrogen, nitro, amino, hydroxyl, lower alkanoyl, lower alkyl, etc.; R 6 is selected from (a) a substituted or unsubstituted phenyl group, (b) a substituted or unsubstituted pyridyl group, (c) a substituted or unsubstituted thienyl group, (d) a substituted or unsubstituted benzofuranyl group, etc.; or a pharmaceutically acceptable salt thereof.

  本发明涉及一种药物组合物，其包含化合物(I)作为活性成分，其中环A是芳香环或杂环；Q是键，羰基，低碳链，低烯链，-O-(低碳链)-等；n为0、1或2；Z为氧或硫；W为氧、硫、-CH═CH-、-NH-或-N═CH-；R1、R2和R3相同或不同，分别为氢、卤素、羟基、取代或未取代的低烷基、取代或未取代的低烷氧基、取代或未取代的氨基等；R4为四唑基、羧基、酰胺或酯基；R5为氢、硝基、氨基、羟基、低烷酰基、低烷基等；R6选自(a)取代或未取代的苯基、(b)取代或未取代的吡啶基、(c)取代或未取代的噻吩基、(d)取代或未取代的苯并呋喃基等；或其药学上可接受的盐。
• 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
  申请人：Balko W. Terry

  公开号：US20080045734A1

  公开（公告）日：2008-02-21

  4-Aminopicolinic acids having tri- and tetra-substituted aryl substituents in the 6-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

  在6位位置上具有三取代和四取代芳基取代基的4-氨基吡啶酸及其胺和酸衍生物是具有广谱除草作用的强效除草剂。
• Method for producing ortho-alkoxybenzoic acid
  申请人：NIPPON CHEMICAL INDUSTRIAL COMPANY LIMITED

  公开号：EP0520815A2

  公开（公告）日：1992-12-30

  o-Methoxy benzoic acid is produced by reacting chlorobenzoic acids having at least one chlorine atom at least at the ortho position with lower alcohol in the presence of a copper salt and a lower alkyl as a catalyst under moderate reaction conditions. o-Methoxy benzoic acid is useful as an intermediate for pharmaceutical, agricultural chemicals, and the like.

  邻甲氧基苯甲酸是在铜盐和低级烷基作为催化剂的存在下，在中等反应条件下，使至少在正位上有一个氯原子的氯苯甲酸与低级醇反应而制得的。