7,7'-二[二(3,5-二甲基苯基)膦基]-4,4'-二甲基-3,3',4,4'-四氢-2H,2'H-8,8'-联-1,4-苯并恶嗪 | 649559-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 7,7'-二[二(3,5-二甲基苯基)膦基]-4,4'-二甲基-3,3',4,4'-四氢-2H,2'H-8,8'-联-1,4-苯并恶嗪
• 中文别名: （S）-7,7'-双[二（3,5-二甲苯基）膦基]-3,3'，4,4'-四氢-4,4'-二甲基-8,8'-二（2H-1,4-苯并恶嗪）
• 英文名称: (R)-7,7 inverted exclamation marka-Bis[di(3,5-xylyl)phosphino]-3,3 inverted exclamation marka,4,4 inverted exclamation marka-tetrahydro-4,4 inverted exclamation marka-dimethyl-8,8 inverted exclamation marka-bi(2H-1,4-benzoxazine)
• 英文别名: [8-[7-bis(3,5-dimethylphenyl)phosphanyl-4-methyl-2,3-dihydro-1,4-benzoxazin-8-yl]-4-methyl-2,3-dihydro-1,4-benzoxazin-7-yl]-bis(3,5-dimethylphenyl)phosphane
• CAS: 649559-70-6
• 化学式: C₅₀H₅₄N₂O₂P₂
• 分子量: 776.9
• InChiKey: NVDNAKSQNFTFDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  56
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• 危险品运输编号：
  UN 2811 6.1/PG 3

文献信息

• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150210657A1

  公开（公告）日：2015-07-30

  A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P represents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group).

  一种制备光学活性胺化合物的方法，其特征在于在存在由通用式（1）或（2）表示的钌配合物的情况下，对一个丙半胱氨基双键进行不对称氢化（其中P代表光学活性二膦，X代表阴离子基团，Ar代表可选择取代的芳基基团）。
• RUTHENIUM COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE ALCOHOL COMPOUND
  申请人：Nara Hideki

  公开号：US20130041151A1

  公开（公告）日：2013-02-14

  The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having ruthenacycle structure, a catalyst for asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol using the ruthenium complex.

  本发明提供了一种新型的钌配合物，该配合物在对羰基化合物的不对称还原反应中具有优异的催化活性和对映选择性，以及使用该钌配合物的催化剂和制备光学活性醇化合物的方法。本发明涉及一种具有钌环结构的钌配合物，一种由该钌配合物组成的不对称还原催化剂，以及使用该钌配合物制备光学活性醇的方法。
• RUTHENIUM COMPOUND AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALCOHOL COMPOUND
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2264000A1

  公开（公告）日：2010-12-22

  A novel ruthenium compound that is useful as an asymmetric reduction catalyst for carbonyl compounds. The ruthenium compound of the present invention is represented by a formula (I): (Ru(X)2(Pxx)[R1R2C(NH2)-R3R4C(NH2)] (I)), and when this compound is used as an asymmetric reduction catalyst, an optically active aminoalcohol compound can be produced from an a-aminoketone, and particularly a compound represented by formula (IV), with high stereoselectivity and high yield.

  一种可用作羰基化合物不对称还原催化剂的新型钌化合物。本发明的钌化合物由式（I）表示：(Ru(X)2(Pxx)[R1R2C(NH2)-R3R4C(NH2)](I))，当该化合物用作不对称还原催化剂时，可以高立体选择性和高产率从a-氨基酮制得光学活性氨基醇化合物，特别是由式(IV)表示的化合物。
• NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST
  申请人：Takasago International Corporation

  公开号：EP2695887A1

  公开（公告）日：2014-02-12

  The present invention provides: a novel ruthenium complex which has excellent catalytic activity with respect to reactivity in the reduction of a multiple bond, in particular, in the asymmetric reduction of a carbonyl compound, enantioselectivity, etc.; a catalyst which comprises the ruthenium complex; and a process for producing optically active compound, in particular, an optically active alcohol compound, using the catalyst. The ruthenium complex has a ruthenacyclic structure. The catalyst is a catalyst for asymmetric reduction which comprises the ruthenium complex.

  本发明提供了：一种新型钌络合物，该钌络合物在多键还原反应，特别是羰基化合物的不对称还原反应、对映选择性等方面具有优异的催化活性；一种包含该钌络合物的催化剂；以及一种使用该催化剂生产光学活性化合物，特别是光学活性醇类化合物的工艺。钌络合物具有钌环结构。催化剂是一种不对称还原催化剂，由钌络合物组成。
• METHOD FOR PREVENTING DECREASE IN OPTICAL PURITY
  申请人：Takasago International Corporation

  公开号：EP2774908B1

  公开（公告）日：2017-02-08