2-Triphenylphosphoranyliden-p-carboxyacetophenon | 56893-09-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Triphenylphosphoranyliden-p-carboxyacetophenon
• 英文别名: 4-[2-(Triphenyl-lambda5-phosphanylidene)acetyl]benzoic acid；4-[2-(triphenyl-λ5-phosphanylidene)acetyl]benzoic acid
• CAS: 56893-09-5
• 化学式: C₂₇H₂₁O₃P
• 分子量: 424.436
• InChiKey: UPGWEHMOULWTQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• DERIVATIVES OF PYRROLOIMIDAZOLE OR ANALOGUES THEREOF WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA CANCER
  申请人：EMCURE PHARMACEUTICALS LIMITED

  公开号：US20190031665A1

  公开（公告）日：2019-01-31

  Present invention relates to novel heterocyclic compounds as indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) modulators. Compounds of the present invention inhibit tryptophan degradation by modulating IDO and/or TDO. The invention further relates to the process of their preparation, pharmaceutical composition and their use in modulating the activity of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO). The compounds of the invention can be used alone or in combination for the treatment of conditions that benefits from the inhibition of tryptophan degradation.